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Aminoglucósidos: información actualizada sobre las indicaciones, la dosificación y el seguimiento
Hazel Moore1,2,3,4,5,6, Daniel Yeoh1,2,3,4,5,6, Carly Hughes1,2,3,4,5,6
1Therapeutic Guidelines Limited, Melbourne.
Australian prescriber
|August 27, 2025
Resumen
Las nuevas pautas australianas hacen hincapié en el peso corporal magro para la dosificación de aminoglucósidos en adultos. El monitoreo terapéutico del fármaco es crucial para la terapia de más de 48 horas, centrándose en el área debajo de la curva.
Área de la Ciencia:
- Farmacología
- Enfermedades infecciosas
- Terapéutica clínica
Sus antecedentes:
- Los aminoglucósidos (gentamicina, tobramicina, amicina) son antibióticos parenterales vitales para las infecciones graves de tipo Gram negativo.
- Estos antibióticos presentan una acción bactericida rápida y bajas tasas de resistencia en Australia.
- Las directrices establecidas para el tratamiento con antibióticos se han actualizado recientemente.
Objetivo del estudio:
- Esbozar una guía actualizada sobre el uso de aminoglucósidos en Australia.
- Detallar las estrategias de dosificación optimizadas y la selección de medicamentos.
- Informar a los médicos sobre las nuevas recomendaciones para el tratamiento de las infecciones Gram negativas.
Principales métodos:
- Revisión y actualización de las Directrices terapéuticas: antibióticos (marzo de 2025).
- Se incluyen nuevas recomendaciones para la dosificación de aminoglucósidos en adultos.
- Desarrollo de calculadoras para el ajuste de dosis.
Principales resultados:
- La dosificación de aminoglucósidos en adultos ahora se basa en el peso corporal magro.
- Hay calculadoras disponibles para ayudar en el cálculo preciso de la dosis.
- Se recomienda la monitorización terapéutica del fármaco durante el tratamiento de más de 48 horas.
Conclusiones:
- Las directrices actualizadas proporcionan estrategias de dosificación y selección de aminoglucósidos optimizadas.
- El peso corporal magro es la base recomendada para la administración en adultos.
- Se recomienda el monitoreo del área bajo la curva de concentración-tiempo durante el tratamiento prolongado con aminoglucósidos.
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