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Efectos prolongados de las restricciones de comportamiento relacionadas con el COVID-19 en el metabolismo óseo
Tatenobu Goto1, Ayako Uemura1, Hiroto Maeda1
1Division of Pediatrics, Yokkaichi Municipal Hospital, Yokkaichi, JPN.
Cureus
|August 27, 2025
Resumen
La pandemia de COVID-19 alteró el metabolismo óseo neonatal, causando aumentos persistentes de fosfato y disminuciones en los niveles de magnesio. El monitoreo continuo es crucial para la salud del bebé a largo plazo.
Área de la Ciencia:
- Medicina neonatal
- La bioquímica
- Salud pública
Sus antecedentes:
- Los cambios en el estilo de vida inducidos por la pandemia de COVID-19 pueden afectar la salud materna y neonatal.
- El metabolismo óseo en los neonatos es sensible a los factores ambientales y de comportamiento.
Objetivo del estudio:
- Evaluar el efecto de las restricciones relacionadas con la pandemia en los marcadores bioquímicos neonatales del metabolismo óseo.
- Para comparar los niveles neonatales de calcio, fosfato, magnesio, hormona paratiroidea intacta (iPTH) y fosfatasa alcalina (ALP) en los períodos pre-pandémico, pandémico y post-pandémico.
Principales métodos:
- Estudio de cohorte retrospectivo de 964 recién nacidos en una NICU japonesa (2018-2024).
- Categoría en grupos pre-COVID-19 (2018-2020), pandemia de COVID-19 (2020-2022) y después de COVID-19 (2022-2024).
- Comparación estadística de los parámetros bioquímicos séricos medidos en el día de la vida.
Principales resultados:
- No hay diferencias significativas en la edad gestacional o el peso al nacer entre los grupos.
- Aumento gradual significativo de los niveles de fosfato sérico desde el período pre-COVID-19 hasta el post-COVID-19 (p<0,01).
- Disminución significativa de los niveles séricos de magnesio en el período posterior a la COVID-19 (p<0,01); no hay cambios en el calcio, la iPTH o la ALP.
Conclusiones:
- Los cambios en el estilo de vida relacionados con la pandemia condujeron a alteraciones significativas y duraderas en el metabolismo neonatal de fosfato y magnesio.
- Estos cambios metabólicos ponen de relieve la necesidad de estrategias de vigilancia e intervención continuas.
- Los hallazgos subrayan la vulnerabilidad del metabolismo óseo neonatal a factores externos.
Palabras clave:
La pandemia del COVID-19cambio en el comportamiento maternoInteracción madre-niñoMetabolismo óseo neonatalSalud del recién nacidoDeficiencia nutricionalImpacto de las pandemiashormonas paratiroideas (pth)Desarrollo postnatalDeficiencia de vitamina DMás Videos Relacionados
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