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Allergic Reactions02:06

Allergic Reactions

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Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Nucleophilic Aromatic Substitution: Elimination–Addition01:11

Nucleophilic Aromatic Substitution: Elimination–Addition

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Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
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Video Experimental Relacionado

Updated: Sep 10, 2025

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

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Anafilaxia por contacto inducida por la clorhexidina

Federico Sandoval Morales1, Fabien Pelletier1, François Aubin1

  • 1Dermatology Department, Allergy Unit, Besançon University Hospital, Besançon, FRA.

Cureus
|August 27, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La anafilaxia perioperatoria severa puede ser provocada por la clorhexidina, un antiséptico común. El aumento de la vigilancia y el cribado preoperatorio son cruciales para identificar a los pacientes en riesgo y prevenir reacciones potencialmente fatales a este agente ampliamente utilizado.

Área de la Ciencia:

  • Anestesiología
  • Alergia e inmunología
  • Seguridad quirúrgica
Palabras clave:
Pruebas cutáneas de alergiasíntomas de alergiaClorhexidina y sus derivadosAlergia a la clorhexidinahipersensibilidad al contactoAnafilaxia perioperatoria

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Sus antecedentes:

  • La clorhexidina es un antiséptico ampliamente utilizado con propiedades antimicrobianas de amplio espectro.
  • La exposición repetida a la clorhexidina puede conducir a la sensibilización, causando reacciones de hipersensibilidad.
  • La anafilaxia perioperatoria es una complicación rara pero grave, con la clorhexidina cada vez más identificada como un desencadenante.