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Eficacia terapéutica de las hierbas ricas en yodo en el tratamiento del hipertiroidismo de Graves: un estudio de
Yiwen Lai1, Mengfei Yang2, Jing Li3
1Department of Endocrinology, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Frontiers in endocrinology
|August 27, 2025
Resumen
Las hierbas ricas en yodo (IRH) tratan eficazmente la enfermedad de Graves, mejorando los niveles de hormonas tiroideas y los títulos de anticuerpos. Esta medicina tradicional china ofrece una alternativa segura a los medicamentos antitiroideos, con una eficacia y persistencia comparables.
Área de la Ciencia:
- Endocrinología
- La medicina tradicional china
- Farmacología
Sus antecedentes:
- La enfermedad de Graves (GD) es un trastorno autoinmune que causa hipertiroidismo.
- Los medicamentos antitiroideos (ATD) son un tratamiento común, pero se buscan alternativas.
- La medicina tradicional china (MTC) ofrece posibles opciones terapéuticas.
Objetivo del estudio:
- Evaluar la eficacia y seguridad de las hierbas ricas en yodo (IRH) como tratamiento de la MTC para el hipertiroidismo de Graves.
- Para comparar la eficacia de la IRH con los fármacos antitiroideos convencionales (ATD).
Principales métodos:
- Estudio de cohorte retrospectivo en el que se comparan los tratamientos de IRH y ATD para la GD.
- La propensión de puntuación de coincidencia (PSM) se utiliza para equilibrar las características del paciente.
- La regresión logística, los modelos de riesgo proporcional de Kaplan-Meier y Cox analizaron la eficacia y los factores que influyen.
Principales resultados:
- La IRH mejoró significativamente los niveles séricos de T3 libre (fT3), T4 libre (fT4), TSH y TRAb en pacientes con DM.
- La eficacia y la persistencia de la IRH fueron comparables a las de la ATD, con perfiles de seguridad similares.
- Las dosis más altas de IRH pueden aumentar la eficacia, mientras que la edad más joven, el sexo masculino, el bocio y la tirotoxicosis severa pueden reducirla.
Conclusiones:
- La IRH es una terapia alternativa segura y eficaz para el hipertiroidismo de Graves de leve a moderado.
- La IRH demuestra una eficacia y duración de acción comparables a las ATD.
- Se requiere una mayor investigación sobre los factores que influyen en la eficacia de la IRH.
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