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Updated: Sep 10, 2025

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast
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Comprender el intercambio de dominio en el dominio c-Src SH3 a través de la mutagénesis de bucle bisagra

M Carmen Salinas-Garcia1, Marina Plaza-Garrido1, Jose C Martinez2

  • 1Department of Chemistry and Physics, University of Almeria, Agrifood Campus of International Excellence (ceiA3) and CIAMBITAL, Carretera de Sacramento s/n, 04120 Almeria, Spain.

Acta crystallographica. Section D, Structural biology
|August 27, 2025
PubMed
Resumen

Al investigar el dominio c-Src SH3, los investigadores intercambiaron las regiones del bucle entre las proteínas c-Src y Abl SH3. La composición del bucle influye en la estabilidad y el intercambio de dominio 3D, pero no es el único impulsor de la formación de dímeros.

Palabras clave:
Intercambio de dominio 3DDominios SH3Interfaz cerrada y primariabucle de bisagrainterfaz abierta/secundaria

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