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Perfiles de riesgo de candidiasis relacionados con medicamentos: un estudio de farmacovigilancia en el mundo real que
Xiaoli Yang1, Tinghua Liu1, Jiaying Lei1
1Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Mycoses
|August 27, 2025
Resumen
Los factores de riesgo de candidiasis relacionados con las drogas incluyen el sexo femenino, la edad avanzada y medicamentos específicos como anticuerpos monoclonales y agentes de quimioterapia. La vigilancia temprana es crucial para medicamentos como la citarabina y la prednisona, que aumentan tanto la susceptibilidad como el riesgo de mortalidad.
Área de la Ciencia:
- Farmacovigilancia de las sustancias
- Enfermedades infecciosas
- Seguridad de las drogas
Sus antecedentes:
- Los perfiles de riesgo para la candidiasis inducida por fármacos no están bien definidos para la mayoría de los medicamentos.
- Comprender estos riesgos es crucial para el manejo clínico y la seguridad del paciente.
Objetivo del estudio:
- Identificar los factores de riesgo para la aparición y la mortalidad de la candidiasis relacionada con las drogas.
- Proporcionar datos para el desarrollo de marcos de estratificación del riesgo clínico.
Principales métodos:
- Se utilizaron datos del Sistema de Notificación de Eventos Adversos de la FDA (FAERS) desde el primer trimestre de 2004 hasta el tercer trimestre de 2024.
- Se utiliza el análisis de desproporcionalidad (ratios de probabilidad de presentación de informes) y la regresión logística multivariable.
- Se analizaron 1526 casos de candidiasis y 200 173 no casos.
Principales resultados:
- Se identificaron 32 factores de riesgo independientes para la candidiasis relacionada con medicamentos, incluido el sexo femenino, la edad ≥65 años, los anticuerpos monoclonales, los antibióticos, los glucocorticoides y los agentes de quimioterapia.
- Cinco fármacos (citarabina, etoposida, prednisona, prednisolona y dexametasona) se asociaron con un aumento de la susceptibilidad y la mortalidad.
- Las clases de fármacos vinculados a la candidiasis también mostraron asociaciones con un aumento de la mortalidad.
Conclusiones:
- Los hallazgos proporcionan referencias esenciales para la estratificación del riesgo clínico de la candidiasis relacionada con medicamentos.
- Destaca los objetivos prioritarios para la investigación futura sobre la patogénesis y la mortalidad de la candidiasis.
Palabras clave:
FAERS (en inglés)reacciones adversas al fármacoCandidiasis en las mujeresanálisis de la desproporcionalidadFarmacovigilancia de las vacunasFactor de riesgoMás Videos Relacionados
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