Video Experimental Relacionado
Updated: Sep 10, 2025
10:28
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
6.5K
Una biofísica del rejuvenecimiento epigenético
1Department of Biomedical Sciences, School of Medicine, Nazarbayev University, 5/1 Kerei, Zhanibek Khandar Street, Astana 010000, Kazakhstan.
Cells
|August 27, 2025
Resumen
Una nueva investigación vincula la edad epigenética (eAge) y la entropía de Shannon con el parámetro de Flory-Huggins (χ) en las células. A medida que las células envejecen, χ disminuye, pero el rejuvenecimiento epigenético puede restaurarlo, revelando las dinámicas clave del envejecimiento.
Área de la Ciencia:
- Biología integradora
- Biofísica computacional
- La epigenética
Sus antecedentes:
- El parámetro de Flory-Huggins (χ) es crucial en la física de polímeros, pero su relevancia nuclear está poco explorada.
- La deriva epigenética y los cambios de paisaje son características del envejecimiento celular.
- La entropía de Shannon cuantifica el desorden de la información y tiene vínculos potenciales con la complejidad biológica.
Objetivo del estudio:
- Establecer nuevas relaciones entre el parámetro de Flory-Huggins (χ), la edad epigenética (eAge) y la entropía de Shannon.
- Para explorar el comportamiento termodinámico de los polímeros dentro del entorno nuclear.
- Investigar el impacto del envejecimiento y el rejuvenecimiento celular en estos parámetros.
Principales métodos:
- Un marco teórico para estimar χ en un contexto nuclear.
- Integración de conceptos de física de polímeros, aprendizaje automático y epigenética.
- Análisis de cómo la deriva epigenética y el rejuvenecimiento influyen en χ, eAge y la entropía de Shannon.
Principales resultados:
- Se ha demostrado la proporcionalidad directa entre χ y eAge (χeAge-1).
- Se estableció una relación entre χ y la entropía de Shannon (χShannon Entropy−1).
- Se demostró que la deriva epigenética reduce χ, mientras que el rejuvenecimiento lo restaura.
Conclusiones:
- El envejecimiento epigenético y la entropía son determinantes clave del parámetro de Flory-Huggins en el núcleo.
- El envejecimiento celular conduce a una disminución de χ debido al alisado del paisaje epigenético.
- El rejuvenecimiento epigenético puede revertir estos cambios, destacando un mecanismo para comprender el envejecimiento y las posibles intervenciones.
Palabras clave:
Parámetro de Flory HugginsH3K27me3 y sus derivadosH3K9me3 y sus derivadosEl Hi-CEntropía de Shannonla reprogramación por edadEdadRejuvenecimiento epigenéticola reprogramación parcialMás Videos Relacionados
Videos de Conceptos Relacionados
01:29Somatic to iPS Cell Reprogramming
2.3K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.3K
01:12Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
01:24Methods of Nuclear Reprogramming
1.9K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.9K
02:15Replicative Cell Senescence
3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K
02:32Histone Modification
13.8K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
13.8K
03:17Inheritance of Chromatin Structures
6.6K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.6K