Video Experimental Relacionado
Updated: Sep 10, 2025
08:08
Author Spotlight: Investigating the Tolerance of Cabbage Butterflies to Urban Pollutants
Published on: August 18, 2023
4.3K
Envenenamiento por plomo en las Américas: fuentes, regulaciones, efectos en la salud y mecanismos moleculares
Blanca Miriam Torres-Mendoza1,2, Asbiel Felipe Garibaldi-Ríos3,4, Lourdes Del Carmen Rizo De La Torre5
1Laboratorio de Inmunodeficiencias y Retrovirus Humanos, División de Neurociencias, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico.
Journal of xenobiotics
|August 27, 2025
Resumen
El envenenamiento por plomo es un problema de salud mundial importante, especialmente en las Américas. Esta revisión pone de relieve las fuentes de exposición emergentes, las lagunas reglamentarias y los riesgos de plomo.
Área de la Ciencia:
- Salud del medio ambiente
- Toxicología
- Política de salud pública
Sus antecedentes:
- El envenenamiento por plomo representa una carga significativa para la salud mundial, que afecta desproporcionadamente a las poblaciones vulnerables en los países en desarrollo.
- La exposición a menudo supera los niveles seguros, con diversos enfoques regulatorios en todas las regiones.
- Las Américas se enfrentan a una exposición ambiental persistente al plomo y a marcos regulatorios variados.
Objetivo del estudio:
- Revisar las fuentes emergentes de exposición al plomo en las Américas.
- Evaluar los avances en las estrategias reglamentarias para la exposición al plomo.
- Analizar los impactos moleculares del plomo en la salud humana.
Principales métodos:
- Revisión de la literatura que se centra en las Américas.
- Análisis de los marcos normativos y de los avances.
- Se utilizó la base de datos toxicogenómica comparativa (CTD) para la evaluación del impacto molecular.
Principales resultados:
- El plomo interactúa con 3448 genes, incluidos los involucrados en la inflamación y el estrés oxidativo.
- El plomo está asociado con 4401 enfermedades y 799 vías moleculares interrumpidas.
- Identificó paisajes regulatorios diversos y a menudo inadecuados en las Américas.
Conclusiones:
- Necesidad urgente de intervenciones adaptadas a la región para combatir la exposición al plomo.
- Las políticas reforzadas y el consenso mundial sobre los niveles de plomo en la sangre son cruciales.
- Se necesitan más investigaciones sobre los efectos moleculares del plomo en la salud.
Videos de Conceptos Relacionados
01:36Types of Toxins
2.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.0K
01:26Toxic Reactions: Overview
1.2K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.2K
01:27The Periodic Table and Organismal Elements
20.1K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
20.1K
01:17Antidotes
756
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
756
01:14Prevention of Further Absorption of Poison
925
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
925
01:26Physical Properties of Amines
3.5K
Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
3.5K