Video Experimental Relacionado

Updated: Sep 10, 2025

Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks

Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks

Published on: March 29, 2018

Las mutaciones genéticas protrombóticas están asociadas con lesiones vasculares placentarias subclínicas: un estudio

Viorela-Romina Murvai^1,2, Anca Huniadi³, Radu Galiș^4,5

¹Doctoral School of Biological and Biomedical Sciences, University of Oradea, 1 University Street, 410087 Oradea, Romania.

Current issues in molecular biology

|August 27, 2025

Resumen

La trombofilia hereditaria está relacionada con lesiones vasculares placentarias específicas y anomalías del cordón umbilical. La puntuación histológica puede ayudar a identificar estos cambios en los embarazos con trombofilia.

Área de la Ciencia:

Patología perinatal
Genética de la trombofilia
Histopatología

Sus antecedentes:

La trombofilia hereditaria es un factor de riesgo conocido para la patología vascular placentaria y los resultados adversos del embarazo.
Existen investigaciones limitadas sobre cambios histopatológicos específicos relacionados con mutaciones de trombofilia durante el embarazo.

Objetivo del estudio:

Investigar sistemáticamente y cuantificar las diferencias histopatológicas de la placenta entre los embarazos con y sin trombofilia hereditaria.
Para correlacionar mutaciones genéticas específicas relacionadas con la trombofilia con las lesiones vasculares placentarias observadas.

Principales métodos:

Estudio observacional retrospectivo de muestras de placenta de mujeres con (Grupo 1) y sin (Grupo 2) trombofilia hereditaria.
Examen macroscópico e histológico de las placentas por patólogos ciegos.
Clasificación y cuantificación de las lesiones utilizando el Consenso de Amsterdam y una puntuación vascular compuesta.

Principales resultados:

Las lesiones placentarias, incluidos los infartos y la trombosis intervilosa, fueron significativamente más frecuentes en el grupo de trombofilia.
Las mutaciones específicas de la trombofilia mostraron correlaciones con los marcadores de lesión vascular placentaria.
Una puntuación histológica compuesta ≥3 se asoció fuertemente con la trombofilia; las anomalías del cordón umbilical también fueron más frecuentes.

Conclusiones:

La trombofilia se asocia con lesiones vasculares placentarias distintas y cuantificables, incluso sin complicaciones clínicas evidentes.
Un sistema de puntuación histológica puede ayudar a identificar la patología placentaria relacionada con la trombofilia.
La integración de datos genéticos e histológicos puede mejorar la evaluación del riesgo perinatal.

Palabras clave:

Polimorfismo del MTHFR el factor V de Leiden mutaciones genéticas Patología placentaria Trombofilia

Más Videos Relacionados

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

Videos de Conceptos Relacionados

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Venous Thrombosis I: Introduction

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.