Video Experimental Relacionado
Updated: Sep 10, 2025
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.8K
Estudio longitudinal de 15 años basado en la población de esclerosis múltiple diagnosticada muy tarde: conocimientos
Claudio Solaro1, Novella Pretti2, Michele Messmer Uccelli3
1Neurology Unit, Galliera Hospital, Genoa, Italy; Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Genoa, Italy.
Multiple sclerosis and related disorders
|August 27, 2025
Resumen
La esclerosis múltiple de aparición muy tardía (VLOMS) en individuos mayores de 60 años muestra una rápida progresión de la discapacidad y una alta mortalidad. La edad al momento del diagnóstico es un predictor clave, que requiere estrategias de manejo personalizadas para esta demografía en evolución de la EM.
Área de la Ciencia:
- Neurología
- Epidemiología
- Enfermedad de los ancianos
Sus antecedentes:
- La epidemiología de la esclerosis múltiple (EM) está cambiando, con más adultos mayores afectados.
- Los datos sobre EM de aparición muy tardía (EMLV), diagnosticada a los 60 años o más, son escasos.
Objetivo del estudio:
- Investigar las características clínicas del VLOMS.
- Para evaluar la progresión de la enfermedad y la discapacidad a largo plazo en pacientes con EMVL.
- Para analizar los datos de la cohorte de EM de Génova.
Principales métodos:
- Análisis retrospectivo de 530 casos incidentes de EM diagnosticados entre 1998 y 2007.
- Se identificaron 38 casos de VLOMS (7,2%).
- Recopilación y análisis de datos de seguimiento durante 15 años.
Principales resultados:
- Los pacientes con EMV fueron diagnosticados a una edad media de 65 años; el 63% tenía EM primaria progresiva.
- La mayoría de los casos de EM recidivante-remitente se convirtieron en EM secundaria progresiva en un plazo de 3,7 años.
- El 92% alcanzó una puntuación EDSS de 6 en 6,3 años; mortalidad del 32% con una supervivencia media a los 10 años.
- Las comorbilidades en el diagnóstico se correlacionan con la supervivencia.
Conclusiones:
- VLOMS se caracteriza por un curso grave de la enfermedad y una rápida acumulación de discapacidad.
- La edad en el momento del diagnóstico es el principal predictor de la progresión de la enfermedad en la EMVO.
- Las estrategias de manejo adaptadas son cruciales para los pacientes con EMVO.
Videos de Conceptos Relacionados
02:20Longitudinal Research
12.4K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.4K
01:26Longitudinal Studies
231
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
231
01:26Introduction to Epidemiology
986
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
986
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
38
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
38
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
34
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
34
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
57
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
57