Video Experimental Relacionado
Updated: Sep 10, 2025
10:21
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
541
El PFOS promueve la proliferación de células de adenocarcinoma pulmonar a través de la EMT mediada por PI3K/AKT/NF-κB
Ruijian Liu1, Qiuyu Yang1, Shanshan Fan1
1Guangdong Provincial Emergency Hospital, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, 466 Middle Xingang Road, Guangzhou, 510317, Guangdong, People's Republic of China.
Resumen
Las sustancias perfluoroalquilo (PFAS) como el PFOS promueven el crecimiento de las células de cáncer de pulmón inhibiendo la apoptosis y aumentando la migración. Este estudio revela que el PFOS activa la vía PI3K/AKT/NF-κB, contribuyendo al desarrollo del adenocarcinoma pulmonar.
Área de la Ciencia:
- Salud del medio ambiente
- Toxicología
- En el campo de la oncología
Sus antecedentes:
- Las sustancias perfluoroalquilo y polifluoroalquilo (PFAS) son sustancias químicas sintéticas muy extendidas.
- La exposición al ácido perfluorooctanesulfónico (PFOS) está relacionada con problemas de salud, pero su papel en el cáncer de pulmón no está claro.
Objetivo del estudio:
- Investigar los efectos del PFOS en las líneas celulares del adenocarcinoma pulmonar (LUAD).
- Elucidar los mecanismos carcinogénicos del PFOS en el LUAD.
Principales métodos:
- Se evaluó la proliferación inducida por PFOS, las propiedades antiapoptóticas y la transición epitelial-mesenquimal (EMT) en las células LUAD H1299 y A549.
- Se examinó la activación de la vía PI3K/AKT/NF-κB y su papel en la inhibición de la apoptosis.
Principales resultados:
- El PFOS promovió significativamente el crecimiento de las células LUAD al suprimir la apoptosis.
- El PFOS aceleró la EMT, mejorando la migración celular.
- El PFOS activó la vía PI3K/AKT/NF-κB, facilitando la proliferación y la migración.
Conclusiones:
- La exposición al PFOS puede exacerbar las afecciones pulmonares o inducir la carcinogénesis.
- El PFOS suprime la apoptosis y activa la señalización PI3K/AKT/NF-κB en el LUAD.
- Los hallazgos proporcionan evidencia del potencial cancerígeno del PFOS en el adenocarcinoma pulmonar.
Palabras clave:
El anti-apoptosisLos demásVía de señalización PI3K/AKT/NF-κBSulfonato de perfluorooctanoLa proliferaciónMás Videos Relacionados
Videos de Conceptos Relacionados
01:22PI3K/mTOR/AKT Signaling Pathway
3.9K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.9K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
01:19Interactions Between Signaling Pathways
6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
01:33Cancer-Critical Genes I: Proto-oncogenes
9.1K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K