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Síndrome POEMS: dos casos para el médico general

Zoe Maikovsky¹, Peter Williams¹

¹University Hospitals Sussex, Worthing Hospital, Lyndhurst Road, Worthing BN11 2DH.

Clinical medicine (London, England)

|August 27, 2025

Resumen

Esta serie de casos destaca la polineuropatía, la organomegalia, la endocrinopatía, la gammopatía monoclonal y el síndrome de anomalías cutáneas (POEMS). El diagnóstico precoz de esta condición rara mejora significativamente los resultados del paciente y la respuesta al tratamiento.

Área de la Ciencia:

Médico interno
Neurología
En el campo de la oncología

Sus antecedentes:

El síndrome POEMS es un trastorno multisistémico raro.
El retraso en el diagnóstico puede tener un impacto negativo en los resultados del paciente.

Objetivo del estudio:

Para explorar el viaje de diagnóstico y los resultados de dos pacientes con síndrome POEMS.
Para resaltar los desafíos en el diagnóstico y el manejo del síndrome POEMS.
Hacer hincapié en el papel de los médicos generales en la atención integral del paciente.

Principales métodos:

Serie de casos que comparan a dos pacientes con el síndrome de POEMS.
Revisión del trabajo de diagnóstico, incluidas las presentaciones atípicas y las investigaciones.
Análisis de la trayectoria de la enfermedad y respuesta al tratamiento.

Principales resultados:

Ambos pacientes presentaron síntomas complejos, lo que llevó a un diagnóstico tardío.
El diagnóstico fue confirmado mediante la identificación de características clave como estenosis arterial atípica, neuropatía, plasmacitoma y aumento de VEGF.
La respuesta al tratamiento y los resultados variaron significativamente entre los dos pacientes.

Conclusiones:

El reconocimiento temprano y el diagnóstico del síndrome POEMS son cruciales para un tratamiento eficaz y una mejor supervivencia.
La colaboración multidisciplinaria y el papel de los médicos generales son vitales para la gestión integral de los pacientes.
Los desafíos en el diagnóstico de enfermedades raras subrayan la necesidad de una mayor concienciación entre los profesionales de la salud.

Palabras clave:

Infarto isquémico atípico Médico general Síndrome de POEMS Síndrome paraneoplásico Enfermedad rara

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