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Updated: Sep 10, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

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Mecanismo y función de GPR3 regulado por un modulador alostérico negativo

Geng Chen1,2,3, Jana Bláhová4, Nico Staffen4

  • 1School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China.

Nature communications
|August 27, 2025
PubMed
Resumen

Los investigadores descubrieron una nueva forma en que los medicamentos pueden bloquear los receptores acoplados a la proteína G (GPCR). Un fármaco llamado AF64394 se dirige a los dímeros GPR3, impidiendo su señalización y ofreciendo nuevas vías para el tratamiento de trastornos metabólicos y del SNC.

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