Video Experimental Relacionado
Updated: May 3, 2026
14:27
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
15.8K
Los perfiles de microbiota intestinal se asocian con diferentes actividades corticales espontáneas en personas
J Ignacio Serrano1, Silvia Cruz-Gil2, Cristina M Fernández2,3
1Computational Models of Intelligence group, Center for Automation and Robotics (CAR, CSIC-UPM), Consejo Superior de Investigaciones Científicas (CSIC), Ctra. Campo Real km 0.200, 28500, Arganda del Rey, Spain. jignacio.serrano@csic.es.
Scientific reports
|August 27, 2025
Resumen
La microbiota intestinal influye en la actividad cerebral en adultos mayores sanos. Los perfiles específicos de bacterias intestinales se correlacionan con la actividad cerebral vinculada a las funciones cognitivas, lo que sugiere que las intervenciones nutricionales pueden retrasar el deterioro cognitivo relacionado con la edad.
Área de la Ciencia:
- La neurociencia
- Microbiología
- Gastroenterología
Sus antecedentes:
- El eje intestino-cerebro es una vía bidireccional que une el intestino y el cerebro.
- La microbiota intestinal regula significativamente la vía intestinal hacia el cerebro.
- Las alteraciones en la microbiota intestinal están relacionadas con afecciones neurológicas y psiquiátricas, pero el mecanismo no está claro.
Objetivo del estudio:
- Investigar cómo la microbiota intestinal influye en la actividad cerebral en personas mayores sanas.
- Para explorar la correlación entre la composición de la microbiota intestinal y la actividad cerebral espontánea.
Principales métodos:
- Análisis de los perfiles de microbiota intestinal en adultos mayores sanos.
- Evaluación de la actividad cerebral espontánea en las áreas corticales posteriores mediales utilizando técnicas de neuroimagen.
Principales resultados:
- Los distintos perfiles de microbiota intestinal se asociaron con diferentes patrones de actividad espontánea en las regiones corticales posteriores mediales.
- Estas regiones del cerebro son cruciales para la memoria, el lenguaje y el procesamiento de las emociones.
Conclusiones:
- Los perfiles de microbiota intestinal no patológicos se correlacionan con la actividad cortical espontánea relacionada con las funciones cognitivas.
- Los hallazgos sugieren que la composición de la microbiota intestinal influye en los cambios cognitivos relacionados con la edad.
- Las intervenciones nutricionales tempranas dirigidas a la microbiota pueden ayudar a mitigar el deterioro cognitivo relacionado con la edad.
Palabras clave:
Densidad de la fuente EEGPerfiles de la microbiota intestinalEje intestino-cerebroPoblación mayor sana.Actividad cortical espontáneaMás Videos Relacionados
Videos de Conceptos Relacionados
01:22Introduction to the Human Microbiota
209
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
209
01:30Development of Human Microbiota
61
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
61
01:27Microbiota of the Stomach and Small Intestine
77
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
77
01:27Microbiota of the Large Intestine
98
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
98
01:18Functions of the Gut Microbiota
233
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
233
01:22Gut-Brain Axis
222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
222