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Trazar las vías evolutivas y filogenéticas del dengue

Talita Émile Ribeiro Adelino^1,2, Marta Giovanetti^3,4,5

¹Central Public Health Laboratory of the State of Minas Gerais, Ezequiel Dias Foundation, Belo Horizonte, Brazil.

Current topics in microbiology and immunology

|August 27, 2025

Resumen

Este resumen es generado por máquina.

La evolución del virus del dengue (DENV) está determinada por los cambios genéticos, el movimiento humano y el clima. Comprender estos factores es clave para controlar la propagación y los brotes de DENV.

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Área de la Ciencia:

Virología
Biología evolutiva
Epidemiología

Sus antecedentes:

El virus del dengue (DENV) es una amenaza significativa para la salud mundial, que causa enfermedades y muertes generalizadas.
Comprender la evolución del DENV es crucial para predecir su propagación y controlar los brotes.

Objetivo del estudio:

Proporcionar una visión global de la diversificación genética y las vías filogenéticas de DENV.
Explorar los factores que influyen en la expansión geográfica y la dinámica de transmisión de DENV.

Principales métodos:

Utilizando la filogenética molecular para analizar las relaciones de cepa DENV.
Aplicación de enfoques filodinámicos para inferir patrones de dispersión viral.
Integración de datos genómicos, epidemiológicos y ecológicos.

Principales resultados:

DENV exhibe una diversificación genética compleja y linajes filogenéticos distintos.
La movilidad humana, el comercio y el clima influyen significativamente en la propagación histórica y la transmisión transfronteriza de DENV.
La adaptación del vector y la urbanización son los principales impulsores ecológicos de la evolución de DENV.

Conclusiones:

Un enfoque multidisciplinario que integre la genómica, la epidemiología y la ecología es vital para la vigilancia y el control eficaces de DENV.
La comprensión mejorada de la evolución de DENV refina los modelos predictivos y las intervenciones de salud pública.
La investigación continua es esencial para mitigar el impacto global de los brotes de DENV.