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Updated: Sep 10, 2025

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
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Un ciclo de señalización impulsado por TRPM2 orquesta el cruce anormal entre órganos en enfermedades cardiovasculares

Maali AlAhmad1, Esra Elhashmi Shitaw2, Asipu Sivaprasadarao2

  • 1Department of Biological Sciences, College of Science, Kuwait University, Alshadadiya, P.O. Box 5969, Safat 130602, Kuwait.

Biomolecules
|August 28, 2025
PubMed
Resumen

El estrés oxidativo conduce a enfermedades cardiovasculares y metabólicas a través de los canales TRPM2, que amplifican las especies reactivas de oxígeno (ROS) y causan daño celular. Este ciclo de canal TRPM2 involucra lisosomas, mitocondrias y núcleos, ofreciendo nuevos objetivos terapéuticos.

Palabras clave:
NOX2 en el airePARP y sus derivadosTRPM2 (en inglés)envejecimientoel calcioEnfermedades cardiovascularesComunicación entre los órganosLos lisosomasenfermedades metabólicasSíndrome metabólicoLas mitocondriasEl estrés oxidativoespecies reactivas de oxígenoel zinc

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