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El estrés oxidativo en la fisiopatología de la enfermedad venosa crónica: una visión general
Sonia Rațiu1,2, Mihaela I Mariș2,3, Adina V Furdui-Lința1,2,3
1Doctoral School Medicine, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, Eftimie Murgu Sq. No. 2, RO-300041 Timișoara, Romania.
Antioxidants (Basel, Switzerland)
|August 28, 2025
Resumen
El estrés oxidativo y el deterioro de la homeostasis redox contribuyen a la enfermedad venosa crónica (ECV) y las venas varicosas (VV). Este estudio pone de relieve su papel en el estrés oxidativo local y sistémico en pacientes con ECV.
Área de la Ciencia:
- Biología vascular
- Fisiopatología
- Investigación sobre el estrés oxidativo
Sus antecedentes:
- La enfermedad venosa crónica (ECV), incluidas las venas varicosas (VV), es una afección multifactorial prevalente que afecta a adultos y ancianos en todo el mundo.
- El aumento de la prevalencia está relacionado con el envejecimiento de la población y la pandemia de obesidad, denominada "flebesidad".
- Los mecanismos fisiopatológicos clave incluyen disfunción endotelial, inflamación, alteración de la hemodinámica y remodelación de la pared venosa, creando hipertensión venosa crónica.
Objetivo del estudio:
- Investigar el papel de la homeostasis redox alterada como mecanismo fisiopatológico en las enfermedades cardiovasculares.
- Presentar evidencia que relacione el deterioro de la homeostasis redox con el estrés oxidativo local y sistémico en pacientes con ECV.
Principales métodos:
- Revisión de las pruebas existentes sobre el estrés oxidativo y las ECV.
- Análisis de los mecanismos fisiopatológicos que contribuyen a la hipertensión venosa crónica.
- Centrarse en el papel de las especies reactivas de oxígeno y la defensa antioxidante en la formación de VV.
Principales resultados:
- El estrés oxidativo, caracterizado por el aumento de las especies reactivas de oxígeno y la reducción de la defensa antioxidante, es un patomecanismo significativo en las enfermedades cardiovasculares y víricas.
- El deterioro de la homeostasis redox se identifica como un factor clave que impulsa el estrés oxidativo local y sistémico crónico en pacientes con ECV.
Conclusiones:
- La homeostasis redox alterada es un mecanismo fisiopatológico crítico subyacente a la enfermedad venosa crónica y sus complicaciones.
- Comprender el papel del estrés oxidativo en las ECV ofrece objetivos potenciales para las intervenciones terapéuticas.
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