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Adipocinas y hepatokinas en la enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD): tendencias
Salvatore Pezzino1,2, Stefano Puleo2, Tonia Luca2,3
1Department of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Biomedicines
|August 28, 2025
Resumen
Este análisis bibliométrico traza las tendencias de investigación en la enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD), destacando temas clave como la resistencia a la insulina y áreas emergentes como la microbiota intestinal y la inflamación para la traducción clínica futura.
Área de la Ciencia:
- * Investigación de la enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD).
- * Interacciones entre la adiposa y el hígado, adipocinas y hepatokinas.
- * Análisis bibliométrico y cartografía científica del paisaje.
Sus antecedentes:
- * El MASLD es un desafío significativo para la salud mundial.
- * Las interacciones complejas entre el tejido adiposo y el hígado son fundamentales para el MASLD.
- * La comprensión actual de las tendencias de la investigación y la traducción clínica en MASLD está fragmentada.
Objetivo del estudio:
- * Mapear sistemáticamente el panorama científico de la investigación MASLD.
- * Identificar las áreas de investigación emergentes y las futuras direcciones de traducción clínica.
- * Analizar las tendencias en los mecanismos de señalización adipoquina- hepatoquina y sus implicaciones clínicas.
Principales métodos:
- * Análisis bibliométrico de 1002 publicaciones (2004-2025).
- * Se utilizó el mapeo temático, la evaluación de tendencias temporales y el análisis de redes.
- * Distribución geográfica evaluada, contribuciones institucionales y evolución de la investigación.
Principales resultados:
- * Estados Unidos y China lideran la producción de investigación; las instituciones europeas sobresalen en los descubrimientos mecanicistas.
- * Los temas principales incluyen la resistencia a la insulina, el hígado graso, el síndrome metabólico, la esteatosis y la fetuina-A.
- * Los temas emergentes incluyen la inflamación, el estrés oxidativo, la microbiota intestinal, el metabolismo lipídico y las respuestas al estrés celular (AMPK, estrés ER).
- * La investigación se ha desplazado hacia modelos integrados que incluyen la microbiota intestinal y la disfunción mitocondrial.
- * Se han identificado nueve grupos principales: vínculos cardiovasculares-metabólicos, vías adipocinas-inflamatorias, control de las hepatokinas y nuevos dominios terapéuticos.
Conclusiones:
- * Este estudio describe las tendencias actuales y las áreas emergentes en la investigación MASLD.
- * Aclara las conexiones entre la investigación mecanicista y la traducción clínica.
- * Proporciona orientación para la investigación y el desarrollo futuros en este campo en rápida evolución.
Palabras clave:
AMPK y sus derivadosEn el caso de losLa adipocina tiene un efecto secundarioFetuína y sus derivadosHepatokina y sus derivadosResistencia a la insulinaBiomarcadores no invasivosEl estrés oxidativoMás Videos Relacionados
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