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Las acciones biológicas de Alamandine: una revisión de alcance
Juliane Flor1,2, Andresa Thomé Silveira1,2, Isabel Amaral Martins1,2
1Laboratório de Fisiologia Translacional, Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre-UFCSPA, Porto Alegre 90050-170, RS, Brazil.
Biomedicines
|August 28, 2025
Resumen
La alamandina (ALA), un péptido en el sistema renina-angiotensina, muestra potencial terapéutico. Ofrece beneficios antiinflamatorios, vasodilatadores y anticancerígenos mediante la modulación de las vías de señalización clave, lo que justifica una mayor investigación.
Área de la Ciencia:
- Farmacología y Fisiología
- Investigación cardiovascular
- Biología molecular
Sus antecedentes:
- El sistema renina-angiotensina (RAS) juega un papel fundamental en la regulación de la presión arterial y el equilibrio de líquidos.
- La alamandina (ALA) es un péptido dentro de la RAS con implicaciones terapéuticas emergentes.
- Comprender los mecanismos de acción del ALA es crucial para desarrollar nuevos tratamientos.
Objetivo del estudio:
- Para mapear sistemáticamente la literatura sobre los mecanismos de acción de Alamandine.
- Identificar los efectos fisiológicos del ALA en varios sistemas.
- Para sintetizar la investigación actual sobre el potencial terapéutico de ALA.
Principales métodos:
- La revisión del alcance se adhiere a la metodología del Instituto Joanna Briggs.
- Una búsqueda exhaustiva de la literatura a través de PubMed, Embase, Scopus y Web of Science.
- La inclusión de estudios in vivo, in vitro e in silico sobre el ALA.
Principales resultados:
- 25 estudios cumplieron los criterios de elegibilidad de los 590 registros iniciales.
- El ALA tiene efectos antiinflamatorios, vasodilatadores, antifibróticos y antiapoptóticos.
- Los mecanismos implican la inhibición de la señalización de MAPK y la modulación de la vía del óxido nítrico.
- El ALA muestra potencial para mitigar el estrés oxidativo y tratar enfermedades cardiovasculares, fibrosis y cáncer.
Conclusiones:
- La alamandina (ALA) tiene un potencial terapéutico significativo, incluyendo propiedades antihipertensivas, antiinflamatorias, antifibróticas y anticancerígenas.
- El ALA parece tener un perfil de seguridad favorable, sin efectos adversos notables reportados.
- Se necesita más investigación para aclarar completamente los mecanismos y las aplicaciones terapéuticas del ALA.
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