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La mitomicina C en el implante de la válvula del glaucoma de Ahmed afecta los resultados quirúrgicos

Wei-Chun Lin¹, Sen Yang¹, Michelle R Hribar¹

¹Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Rd, Portland, OR 97239, USA.

Bioengineering (Basel, Switzerland)

|August 28, 2025

Resumen

Las inyecciones complementarias de mitomicina C (MMC) mejoraron los resultados a corto plazo de la cirugía de válvula de glaucoma de Ahmed (AGV) al reducir la presión intraocular (IOP). Sin embargo, estos beneficios no se mantuvieron a largo plazo, sin diferencias significativas en 12 meses.

Área de la Ciencia:

Oftalmología
Innovación quirúrgica
Tratamiento del glaucoma

Sus antecedentes:

El glaucoma es una de las principales causas de ceguera irreversible a nivel mundial.
La implantación de Ahmed Glaucoma Valve (AGV) es una intervención quirúrgica común para el glaucoma.
La mitomicina C (MMC) es un agente anti-fibrótico con potencial para prevenir el fallo de la VGA.

Objetivo del estudio:

Evaluar los resultados quirúrgicos de la implantación de AGV con inyecciones adicionales de Mitomicina C (MMC).
Para comparar los resultados entre los pacientes que recibieron AGV con MMC frente a AGV solo.
Evaluar la eficacia a corto y largo plazo de MMC adjunto en cirugía AGV.

Principales métodos:

Diseño retrospectivo del estudio de casos y controles.
La inclusión de 142 ojos sometidos a implantación AGV.
Comparación de los resultados entre 50 ojos con MMC adjunto y 92 ojos sin MMC.

Principales resultados:

La administración de MMC redujo significativamente la presión intraocular (PIO) a los 1, 3 y 6 meses después de la cirugía.
El grupo de MMC requirió menos medicamentos para el glaucoma a corto plazo (1-6 meses).
No se observaron diferencias estadísticamente significativas en la PIO o en el uso de medicamentos a los 12 meses.

Conclusiones:

Adjunto MMC mejora los resultados quirúrgicos a corto plazo en los implantes de glaucoma AGV.
Los beneficios del MMC adjunto en la PIO y el uso de medicamentos son transitorios, no sostenidos a largo plazo.
Aunque asociado con hipotonía transitoria, el MMC adjunto no condujo a complicaciones a largo plazo.

Palabras clave:

descubrimiento de fármacos el glaucoma Mitomicina C y sus derivados Investigación de resultados cirugía cicatrización de heridas

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