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Explorando la asociación entre la deficiencia de glucosa-6-fosfato deshidrogenasa y el trastorno del espectro
Maitha Abdulla Alshamsi1, Maitha Tareq Al Teneiji1, Subhranshu Sekhar Kar2
1RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al-Khaimah P.O. Box 11172, United Arab Emirates.
Children (Basel, Switzerland)
|August 28, 2025
Resumen
La deficiencia de glucosa-6-fosfato deshidrogenasa (G6PD) puede estar relacionada con el trastorno del espectro autista (TEA). Se necesita más investigación para explorar el estrés oxidativo y el metabolismo del folato como posibles conexiones entre la deficiencia de G6PD y el TEA.
Área de la Ciencia:
- La neurociencia
- La genética
- La bioquímica
Sus antecedentes:
- El trastorno del espectro autista (TEA) es una condición compleja del desarrollo neurológico.
- La deficiencia de glucosa-6-fosfato deshidrogenasa (G6PD) es una enzimopatía común de los glóbulos rojos.
- La investigación emergente sugiere un vínculo potencial entre la deficiencia de G6PD y los trastornos del desarrollo neurológico como el TEA.
Objetivo del estudio:
- Explorar la posible asociación entre la deficiencia de G6PD y el TEA.
- Revisar la literatura existente sobre la conexión entre estas dos condiciones.
- Identificar los posibles mecanismos biológicos que vinculan la deficiencia de G6PD y el TEA.
Principales métodos:
- Revisión narrativa de la literatura científica.
- Las búsquedas realizadas en las bases de datos de PubMed y Scopus.
- Análisis de estudios que investigan la deficiencia de G6PD y el autismo.
Principales resultados:
- La evidencia sugiere vínculos biológicos plausibles entre la deficiencia de G6PD y el TEA.
- El estrés oxidativo y el metabolismo del ácido fólico se identifican como áreas clave de interés.
- La deficiencia de G6PD puede actuar como un modificador de riesgo en el TEA.
Conclusiones:
- Una posible conexión entre la deficiencia de G6PD y el TEA justifica una mayor investigación.
- La comprensión de esta relación podría tener implicaciones para la práctica clínica y la evaluación de riesgos.
- Se necesita más investigación para aclarar completamente la naturaleza de esta asociación.
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