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Terapias actuales y emergentes dirigidas a las proteínas arginina metiltransferasas (PRMT) en el cáncer
Adriana Kaganovski1, Bayle Smith-Salzberg1, Hadar K Shimshon1
1College of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.
International journal of molecular sciences
|August 28, 2025
Resumen
Las proteínas metiltransferasas de arginina (PRMT) regulan la expresión génica y los procesos celulares. Esta revisión hace hincapié en los PRMT
Área de la Ciencia:
- La epigenética y la biología molecular
- Investigación del cáncer
- Farmacología
Sus antecedentes:
- Las proteínas metiltransferasas de arginina (PRMT) son enzimas que catalizan la metilación de la arginina, una modificación crucial después de la traducción.
- Los PRMT funcionan como reguladores epigenéticos que influyen en la expresión génica, la transducción de señales y la proliferación celular.
- La actividad aberrante de PRMT está implicada en la progresión de varios cánceres, incluidos el cáncer de mama, pulmón y colorrectal, a menudo correlacionado con un mal pronóstico.
Objetivo del estudio:
- Revisar las funciones específicas de los PRMT individuales en el desarrollo y la progresión del cáncer.
- Resaltar los avances recientes en el desarrollo de inhibidores de la PRMT como agentes terapéuticos potenciales.
- Hacer hincapié en el potencial terapéutico de la orientación de las PRMT en oncología.
Principales métodos:
- Revisión exhaustiva de la literatura de los estudios preclínicos y clínicos sobre los PRMT en el cáncer.
- Análisis de la investigación sobre la desregulación de las PRMT en varios tipos de cáncer.
- Evaluación de la eficacia y el potencial terapéutico de los nuevos inhibidores de la PRMT.
Principales resultados:
- Los PRMT desempeñan diversas funciones en el cáncer, y su desregulación contribuye a la tumorigénesis.
- Numerosos compuestos novedosos dirigidos a la actividad de PRMT han demostrado efectos terapéuticos significativos en estudios preclínicos y clínicos.
- La sobreexpresión de PRMT está asociada con peores resultados en pacientes con múltiples tipos de cáncer.
Conclusiones:
- Los PRMT son reguladores críticos en el cáncer, lo que los convierte en objetivos terapéuticos prometedores.
- Los inhibidores emergentes de la PRMT muestran un potencial significativo para el tratamiento del cáncer.
- Es esencial realizar más investigaciones para aclarar plenamente la utilidad terapéutica de los PRMT en oncología.
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