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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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El impacto de la cirugía bariátrica en la composición y diversidad de la microbiota intestinal: un análisis
Radu Petru Soroceanu1,2, Daniel Vasile Timofte1,2, Sergiu Timofeiov1,2
1Department of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
International journal of molecular sciences
|August 28, 2025
Resumen
La cirugía bariátrica altera significativamente la composición de la microbiota intestinal, promoviendo un equilibrio microbiano más saludable. Estos cambios se correlacionan con la mejora de la obesidad y los marcadores de salud metabólica después de la cirugía.
Área de la Ciencia:
- Investigación del microbioma
- Cirugía metabólica
- Medicamento para la obesidad
Sus antecedentes:
- La cirugía bariátrica es el tratamiento más eficaz para la obesidad, pero los mecanismos no están claros.
- La microbiota intestinal influye en la regulación metabólica y es alterada por procedimientos bariátricos.
Objetivo del estudio:
- Para evaluar los cambios dinámicos de la microbiota intestinal después de la gastrectomía de manga laparoscópica (LSG) y el bypass gástrico Roux-en-Y (RYGB).
- Evaluar los cambios en la microbiota a los 3 y 6 meses después de la cirugía en pacientes obesos.
Principales métodos:
- Estudio prospectivo de un solo centro.
- Secuenciación de genes de ARNr 16S (regiones V3-V4) de muestras fecales.
- Análisis antes de la cirugía (T0), 3 meses (T3) y 6 meses (T6).
Principales resultados:
- Cambios significativos en la diversidad y estructura microbiana observados después de la cirugía.
- Reducción de la relación Firmicutes/Bacteroidetes y aumento de las Actinobacteria, Proteobacteria y Verrucomicrobia.
- Tendencia de normalización de la microbiota correlacionada con el IMC y mejoras metabólicas.
Conclusiones:
- La cirugía bariátrica induce modificaciones favorables y sostenidas de la microbiota intestinal.
- Estos cambios microbianos pueden contribuir a los efectos terapéuticos de la cirugía bariátrica en el tratamiento de la obesidad.
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