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Quercetina en la fibrosis pulmonar idiopática y sus comorbilidades: mecanismos de regulación genética e implicaciones
Verónica Rocío Vásquez-Garzón1,2,3, Juan Manuel Velázquez-Enríquez1,4, Jovito Cesar Santos-Álvarez1
1Laboratorio de Fibrosis y Cáncer, Facultad de Medicina y Cirugía, Universidad Autónoma Benito Juárez de Oaxaca, Ex Hacienda de Aguilera S/N, Sur, San Felipe del Agua, Oaxaca C.P. 68020, Mexico.
Genes
|August 28, 2025
Resumen
La quercetina, un flavonoide natural, es prometedora para el tratamiento de la fibrosis pulmonar idiopática (FIP) y condiciones relacionadas. Sus efectos antioxidantes y antiinflamatorios se dirigen a las vías fibróticas clave y las comorbilidades, ofreciendo un nuevo potencial terapéutico.
Área de la Ciencia:
- Pulmonología
- Farmacología
- Biología molecular
Sus antecedentes:
- La fibrosis pulmonar idiopática (FIP) es una enfermedad pulmonar progresiva con opciones de tratamiento limitadas.
- Las comorbilidades tienen un impacto significativo en la progresión de la FPI y en los resultados de los pacientes.
- La quercetina, un flavonoide, posee propiedades antioxidantes, antiinflamatorias y antifibróticas.
Objetivo del estudio:
- Revisar el papel multifacético de la quercetina en la FPI y sus comorbilidades.
- Para resaltar los mecanismos de regulación genética de la quercetina en la enfermedad.
- Para explorar el potencial de la quercetina como estrategia terapéutica.
Principales métodos:
- Revisión de los estudios preclínicos y clínicos sobre la quercetina en la FPI.
- Análisis de la modulación de las vías moleculares de la quercetina (Nrf2, SIRT1/AMPK, miRNA).
- Examen de los efectos de la quercetina en las comorbilidades relacionadas con la FPI.
Principales resultados:
- La quercetina modula las vías moleculares clave involucradas en la patogénesis de la FPI.
- La quercetina demuestra un potencial terapéutico para las comorbilidades IPF como la EPOC, las enfermedades cardiovasculares y la diabetes.
- La quercetina actúa a través de la modulación epigenética de los miARN y la regulación del estrés oxidativo/inflamación.
Conclusiones:
- La quercetina presenta un potencial significativo como tratamiento complementario o alternativo para la FPI.
- La eficacia de la quercetina se extiende al tratamiento de las comorbilidades relacionadas con la FPI.
- Se necesitan más investigaciones sobre los mecanismos de regulación genética de la quercetina para el tratamiento de la FPI.
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