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Updated: May 12, 2026
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Using a Comparative Species Approach to Investigate the Neurobiology of Paternal Responses
Published on: September 19, 2011
12.7K
Comportamiento alterado y actividad neuronal con eliminación paterna
Daniel S Scott1, Violeta Zaric2, Carol A Tamminga1,3
1Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Genes
|August 28, 2025
Resumen
La eliminación del gen Snord116 en ratones con síndrome de Prader-Willi (PWS) aumenta la actividad neuronal en regiones clave del cerebro. Este cambio genético está relacionado con comportamientos parecidos a la psicosis, particularmente bajo estrés.
Área de la Ciencia:
- La neurociencia
- La genética
- Ciencias del comportamiento
Sus antecedentes:
- El síndrome de Prader-Willi (PWS) es un trastorno del desarrollo neurológico caracterizado por problemas de comportamiento, incluida la psicosis.
- PWS está relacionado con la eliminación o el silenciamiento de la copia paterna del cromosoma 15q11-13.
- El gen Snord116 dentro de esta región juega un papel crítico en la manifestación de PWS.
Objetivo del estudio:
- Investigar cómo la microdeleción del gen Snord116 paterno afecta la actividad neuronal en las regiones cerebrales asociadas a la psicosis.
- Para evaluar el impacto de la eliminación de Snord116 en comportamientos similares a la psicosis en un modelo de ratón.
Principales métodos:
- Se evaluó la actividad neuronal regional utilizando la expresión de c-Fos en áreas cerebrales específicas de ratones.
- Fenotipos de comportamiento evaluados relacionados con la psicosis en ratones con microdeleción Snord116.
- Utilizó paradigmas estresantes para identificar déficits de comportamiento y condicionamiento alterado del miedo.
Principales resultados:
- La deleción de Snord116 condujo a un aumento de la expresión de c-Fos en el hipocampo y la corteza cingulada anterior.
- Los ratones que carecían de Snord116 exhibieron comportamientos consistentes con la psicosis, incluidos los déficits de la puerta sensoriomotriz.
- Se observó un acondicionamiento de miedo contextual y acondicionado en ratones eliminados de Snord116.
Conclusiones:
- El estudio implica a los objetivos de Snord116 en el desarrollo de estados similares a la psicosis.
- Los efectos observados de la deleción de Snord116 en la actividad neuronal y el comportamiento muestran especificidad regional.
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