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Exploración de los sistemas eutecticos de ibuprofeno y mentol: propiedades fisicoquímicas y citotoxicidad para

Álvaro Werner¹, Estefanía Zuriaga¹, Marina Sanz¹

¹Facultad de Ciencias de la Salud, Universidad San Jorge, Campus Universitario, Autov. A23 km 299, 50830 Villanueva de Gállego, Zaragoza, Spain.

|August 28, 2025

Resumen

Se desarrollaron sistemas eutecticos de ibuprofeno-mentol para mejorar la administración de fármacos. Algunas formulaciones demostraron una toxicidad reducida en líneas celulares específicas, lo que indica un potencial para aplicaciones farmacéuticas más seguras.

Área de la Ciencia:

Ciencias Farmacéuticas
Ciencias de los materiales

Sus antecedentes:

Los sistemas eutecticos están ganando terreno en la investigación farmacéutica para mejorar la formulación y administración de medicamentos.
Los ingredientes farmacéuticos activos (API) a menudo requieren métodos de administración innovadores para mejorar la eficacia.

Objetivo del estudio:

Preparación y caracterización de sistemas terapéuticos eutecticos (THEES) con el uso de ibuprofeno y mentol.
Evaluar las propiedades fisicoquímicas, reológicas y citotóxicas de estos nuevos sistemas eutécticos.

Principales métodos:

Preparación de sistemas eutécticos de ibuprofeno y mentol en diferentes proporciones molares.
Evaluación de las propiedades fisicoquímicas (densidad, índice de refracción, etc.) y el comportamiento reológico.
Evaluación de la citotoxicidad utilizando líneas celulares HaCaT y HepG2.

Principales resultados:

Todos los sistemas preparados dieron como resultado líquidos transparentes, viscosos y monofásicos.
Las propiedades físico-químicas exhibieron relaciones inversas dependientes de la temperatura. La viscosidad siguió la ecuación de Vogel-Fulcher-Tammann, lo que indica un comportamiento no newtoniano.
La citotoxicidad varió; Ibu-M3 mostró una toxicidad reducida en las células HaCaT y HepG2 en comparación con los compuestos puros, mientras que otras proporciones mostraron toxicidad diferencial.

Conclusiones:

Los sistemas eutecticos de ibuprofeno-mentol poseen propiedades fisicoquímicas y reológicas favorables para el procesamiento farmacéutico.
Las composiciones eutecticas específicas demuestran potencial para mejorar la biocompatibilidad, lo que sugiere su utilidad en el desarrollo de formulaciones farmacológicas más seguras.

Palabras clave:

Sistemas eutécticos terapéuticos citotoxicidad el ibuprofeno Acido acético Propiedades fisicoquímicas

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