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Nanocarriers en el suministro de drogas Ungual
Sheila Porto de Matos1, Karen de Oliveira Araujo1, Tainá Kreutz1
1Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre 90610-000, Brazil.
Pharmaceutics
|August 28, 2025
Resumen
La nanotecnología ofrece soluciones prometedoras para administrar medicamentos a las uñas, superando los desafíos de barrera planteados por trastornos ungual como la onicomicosis. Sin embargo, la falta de pruebas estandarizadas de permeación de uñas dificulta el análisis comparativo de estos sistemas avanzados de administración de fármacos.
Área de la Ciencia:
- Ciencias farmacéuticas
- Biotecnología
- Dermatología
Sus antecedentes:
- Los trastornos de las uñas, como la onicomicosis y la psoriasis de las uñas, afectan significativamente la calidad de vida del paciente.
- La estructura densa y queratinizada de la placa de la uña crea una barrera significativa, lo que complica la administración efectiva de medicamentos para el tratamiento de las afecciones de las uñas.
- Los tratamientos sistémicos y tópicos actuales para los trastornos ungual enfrentan desafíos de biodisponibilidad debido a las propiedades inherentes de la uña.
Objetivo del estudio:
- Revisar los actuales sistemas de administración de fármacos nanoestructurados diseñados para el tratamiento tópico de trastornos no orales.
- Explorar los avances tecnológicos destinados a mejorar la biodisponibilidad de los fármacos en la placa ungueal.
- Identificar los desafíos y las limitaciones en el campo, especialmente en lo que respecta a las metodologías de evaluación.
Principales métodos:
- Extensa revisión de la literatura de los sistemas nanoestructurados para el tratamiento de trastornos ungual.
- Análisis de estrategias para mejorar la penetración de fármacos a través de la barrera de las uñas.
- Evaluación de las metodologías existentes para evaluar la permeación del fármaco en las uñas.
Principales resultados:
- Los sistemas basados en nanotecnología muestran potencial para aumentar la biodisponibilidad del fármaco en la placa ungueal.
- La combinación de la nanotecnología con otros métodos puede mejorar aún más la permeación de medicamentos.
- Se identificó una falta significativa de estandarización en los métodos de evaluación de la permeabilidad de las uñas en todos los estudios.
Conclusiones:
- Los sistemas nanoestructurados representan una vía prometedora para el tratamiento localizado de trastornos ungual.
- La estandarización de las pruebas de penetración de uñas es crucial para evaluar y comparar la eficacia de los nuevos sistemas de administración de fármacos.
- Se necesita más investigación para optimizar y validar estos enfoques nanotecnológicos para su aplicación clínica.
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