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Entrega oral de extracto de cáscara de aguacate utilizando nanoportadores de albúmina para modular la absorción de
Laura M Teixeira1,2,3, Ana S Viana1,2, Catarina P Reis3,4
1Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
Pharmaceutics
|August 28, 2025
Resumen
La nanoencapsulación de extracto de cáscara de aguacate en nanopartículas de albúmina sérica bovina mejora su estabilidad y biodisponibilidad. Este nuevo sistema de administración muestra potencial para controlar la hipercolesterolemia mediante la reducción de la absorción de colesterol.
Área de la Ciencia:
- Biotecnología
- La nanomedicina
- Productos nutracéuticos
Sus antecedentes:
- La hipercolesterolemia es un importante factor de riesgo de enfermedades cardiovasculares, con los medicamentos actuales que causan efectos adversos.
- Los productos naturales ofrecen alternativas, pero la escasa biodisponibilidad requiere sistemas avanzados de administración.
- El extracto de cáscara de aguacate (Persea americana) muestra potencial para reducir el colesterol.
Objetivo del estudio:
- Desarrollar y caracterizar las nanopartículas de albúmina sérica bovina que encapsulan el extracto de la cáscara de Persea americana.
- Evaluar la estabilidad, seguridad y biodisponibilidad de la nanoformulación.
- Evaluar la eficacia de la nanoformulación en la reducción de la absorción del colesterol.
Principales métodos:
- El extracto de cáscara de aguacate fue encapsulado en nanopartículas de albúmina sérica bovina.
- Se evaluaron las propiedades fisicoquímicas, la estabilidad y la citotoxicidad de la nanoformulación.
- La biodisponibilidad y la absorción de colesterol se evaluaron utilizando modelos de células Caco-2.
Principales resultados:
- La nanoencapsulación mejoró la estabilidad y la biodisponibilidad del extracto, protegiéndolo durante la digestión simulada.
- Las nanopartículas mostraron propiedades fisicoquímicas favorables y demostraron seguridad y biocompatibilidad.
- La nanoformulación redujo significativamente la permeación de colesterol en las células Caco-2 en comparación con el extracto libre.
Conclusiones:
- La nanoformulación de extracto de cáscara de aguacate ofrece un sistema de administración oral estable y biodisponible.
- Esta nanoformulación presenta una estrategia prometedora y segura para el manejo de la hipercolesterolemia.
- Se sugieren otras aplicaciones en el tratamiento de trastornos metabólicos.
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