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El parto sublingual y bucal: una prescripción histórica y científica
Sina Bahraminejad1, Hassan Almoazen1
1Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Rm 661, Memphis, TN 38018, USA.
Pharmaceutics
|August 28, 2025
Resumen
La administración sublingual y bucal de fármacos ha evolucionado significativamente en 75 años, con cuatro períodos de crecimiento distintos. La investigación ahora se centra en la administración avanzada de la mucosa para mejorar los beneficios terapéuticos.
Área de la Ciencia:
- Farmacología y farmacéutica
- Sistemas de administración de fármacos
- Entrega de fármacos por las mucosas
Sus antecedentes:
- Las vías de administración sublingual y bucal de medicamentos se han explorado durante más de 75 años.
- Las primeras investigaciones (1950-1982) mostraron una exploración limitada de estas vías mucosas.
- Se han producido avances significativos, especialmente desde la década de 1980.
Objetivo del estudio:
- Revisar el desarrollo histórico de la administración sublingual y bucal de medicamentos en los últimos 75 años.
- Identificar las fases clave y las innovaciones en este campo.
- Para resaltar el creciente enfoque de la investigación en la administración de fármacos por la mucosa.
Principales métodos:
- Revisión de la literatura basada en la consulta "sublingual y bucal".
- Análisis de las tendencias de publicación de 1950 a 2025.
- Categoría de la investigación en períodos de crecimiento distintos.
Principales resultados:
- Se identificaron cuatro períodos de crecimiento distintos en la investigación de la entrega sublingual y bucal: Temprano (1950-1982), Exploratorio (1983-1993), Diversificación (1994-2009) e Innovación (2010-2025).
- Documentó la expansión de agentes terapéuticos y tecnologías de formulación, incluidas las nanopartículas, los sistemas mucoadhesivos y las formulaciones pediátricas.
- Observó el uso creciente para diversas afecciones, desde angina y hipertensión hasta tratamiento del dolor, trastorno por uso de opiáceos y administración de vacunas.
Conclusiones:
- La administración sublingual y bucal de fármacos representa un área dinámica y en expansión de la investigación farmacéutica.
- El análisis histórico revela una trayectoria de innovación continua, impulsada por la necesidad de mejorar la eficacia de los medicamentos y el cumplimiento de los pacientes.
- La investigación futura está preparada para mejorar aún más la administración de fármacos por la mucosa tanto para los resultados terapéuticos locales como sistémicos.
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