Video Experimental Relacionado
Updated: Sep 9, 2025
05:11
Inkjet-printed Polyvinyl Alcohol Multilayers
Published on: May 11, 2017
12.7K
Desarrollo y caracterización de mezclas de polímeros a base de alcohol polivinílico para su aplicación como forma de
Zarina A Kenessova1, Grigoriy A Mun1,2, Perizat I Urkimbayeva1
1Department of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.
Polymers
|August 28, 2025
Resumen
El alcohol polivinílico (PVA) y los hidrogeles de metilcelulosa (MC) muestran una mayor hinchazón en la saliva artificial y propiedades mucoadhesivas. Estos hidrogeles PVA-MC son prometedores para los sistemas de administración bucal de fármacos.
Área de la Ciencia:
- Ciencia de los Polímeros
- Ciencias de los materiales
- Ciencias farmacéuticas
Sus antecedentes:
- Los hidrogeles son cruciales en la administración de medicamentos debido a su biocompatibilidad y propiedades sintonizables.
- El alcohol polivinílico (PVA) y la metilcelulosa (MC) son polímeros ampliamente utilizados para la síntesis de hidrogel.
- El desarrollo de sistemas eficaces de administración bucal de fármacos requiere materiales con características específicas de inflamación y mucoadhesión.
Objetivo del estudio:
- Sintetizar y caracterizar los hidrogeles de alcohol polivinílico (PVA) y de metilcelulosa (MC).
- Investigar el comportamiento de inflamación y la cinética de sorción/liberación del ingrediente farmacéutico activo (API) de estos hidrogeles.
- Evaluar las propiedades mucoadhesivas de los hidrogeles PVA-MC para posibles aplicaciones de administración bucal de fármacos.
Principales métodos:
- Síntesis de hidrogeles de PVA-MC en varias proporciones de componentes.
- Estudio de la cinética de la inflamación del hidrogel en agua y saliva artificial.
- Investigación de los perfiles de sorción y liberación de API.
- Evaluación de la mucoadhesión utilizando modelos de la mucosa de las mejillas de los cerdos.
Principales resultados:
- Los hidrogeles mostraron una hinchazón significativamente mayor en la saliva artificial en comparación con el agua.
- El aumento del contenido de PVA se correlacionó con un mayor grado de hinchazón y capacidad de sorción de API.
- La tasa de liberación de API disminuyó con un mayor contenido de PVA.
- Los hidrogeles de PVA-MC demostraron una mucoadhesión significativa, con una relación de 6:4 que se mantuvo durante hasta dos días.
Conclusiones:
- Los hidrogeles de PVA-MC poseen propiedades de inflamación y liberación de fármacos ajustables.
- El potencial mucoadhesivo de estos hidrogeles los hace adecuados para la administración bucal de fármacos.
- Los hidrogeles sintetizados de PVA-MC son prometedores para aplicaciones médicas y farmacológicas.
Palabras clave:
Ingrediente farmacéutico activoHidrogeles y sus derivadosMetilcelulosa y sus derivadosPropiedades mucoadhesivasAlcohol polivinílico y sus derivadosMás Videos Relacionados
Videos de Conceptos Relacionados
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
192
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
192
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
399
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
399
01:21Polymer Classification: Crystallinity
3.1K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
3.1K
01:24Characteristics and Nomenclature of Copolymers
2.7K
Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
2.7K
01:26Polymer Classification: Stereospecificity
2.6K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
2.6K
01:20Anionic Chain-Growth Polymerization: Overview
2.2K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.2K