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Nanofibras basadas en ciclodextrina / PVP con extracto de Radiola rosea como un nuevo sistema para aumentar la
Maciej Jaskólski1, Magdalena Paczkowska-Walendowska1, Zuzanna Rybarczyk1
1Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Molecules (Basel, Switzerland)
|August 28, 2025
Resumen
Las nanofibras de electrospun mejoraron la administración del extracto de Rhodiola rosea, mejorando la biodisponibilidad de la salidrosida y la rosarina. Estos sistemas de ciclodextrina-PVP son prometedores para la administración de los bioactivos de Rhodiola rosea.
Área de la Ciencia:
- Farmacología
- Ciencias de los materiales
- Biotecnología
Sus antecedentes:
- Rhodiola rosea contiene compuestos bioactivos como el salidroside y la rosarina.
- La mejora de la biodisponibilidad de estos compuestos es crucial para la eficacia terapéutica.
- Las nanofibras de electrospun ofrecen un nuevo sistema de administración de fármacos.
Objetivo del estudio:
- Para optimizar la extracción de Rhodiola rosea.
- Desarrollar y optimizar los sistemas de nanofibras electrospuestas para mejorar la biodisponibilidad de la salidrosida y la rosarina.
- Evaluar las propiedades funcionales y tecnológicas de estos sistemas.
Principales métodos:
- Diseño de experimentos (DoE) para la formulación de nanofibras.
- Preparación de nanofibras mediante el uso de polivinilpirrolidona (PVP) y hidroxipropil-ciclodextrinas (HPαCD, HPβCD, HPγCD).
- Caracterización completa que incluye análisis de morfología, contenido de compuestos activos, disolución, permeabilidad, mucoadhesión, antioxidantes y antiinflamatorios. Se utilizó el análisis de componentes principales (PCA).
Principales resultados:
- Las formulaciones de nanofibra mejoraron significativamente la disolución y la permeabilidad de la salidrosida y la rosarina.
- Se observaron propiedades antioxidantes mejoradas.
- La formulación con 3 g de HPβCD y 2,5 g de PVP mostró propiedades funcionales y tecnológicas óptimas.
- PCA confirmó la bioactividad y las propiedades dependientes de la composición.
Conclusiones:
- Las nanofibras de electrospun basadas en matrices de ciclodextrina-PVP son una estrategia prometedora para mejorar la entrega bioactiva de Rhodiola rosea.
- Este enfoque mejora la biodisponibilidad y la bioactividad de los compuestos clave.
- Se necesitan más estudios preclínicos.
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