Video Experimental Relacionado
Updated: Sep 9, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
29.3K
Alimentos ultraprocesados, microbiota intestinal y enfermedad inflamatoria intestinal: una revisión crítica de la
Amanda Luísa Spiller1, Beatriz Gabriela da Costa1, Ryan Nunes Yoshio Yoshihara1
1Department of Internal Medicine, Medical School, São Paulo State University (Unesp), Botucatu 18618-686, SP, Brazil.
Nutrients
|August 28, 2025
Resumen
El alto consumo de alimentos ultraprocesados (UPF) está relacionado con la disbiosis intestinal, lo que podría aumentar el riesgo de enfermedades inflamatorias intestinales (IBD). Esta disbiosis implica una diversidad microbiana reducida y una función de barrera intestinal deteriorada, lo que contribuye a la inflamación crónica.
Área de la Ciencia:
- Gastroenterología
- Microbiología
- Ciencias de la nutrición
Sus antecedentes:
- Las enfermedades inflamatorias intestinales (EII), incluida la enfermedad de Crohn y la colitis ulcerosa, son afecciones inflamatorias gastrointestinales crónicas.
- La fisiopatología de la EII involucra factores genéticos y ambientales, con una prevalencia creciente a nivel mundial.
- El aumento del consumo de alimentos ultraprocesados (UPF) es paralelo al aumento de los casos de EII.
Objetivo del estudio:
- Examinar críticamente la influencia del consumo de UPF en la composición y función de la microbiota intestinal.
- Investigar el posible vínculo entre la ingesta de UPF y el desarrollo de EII.
Principales métodos:
- Búsqueda bibliográfica realizada en las bases de datos SciELO, PubMed y Cochrane.
Principales resultados:
- El alto consumo de UPF está asociado con disbiosis intestinal.
- Disbiosis caracterizada por una diversidad microbiana reducida, disminución de la producción de ácidos grasos de cadena corta y deterioro de la integridad de la barrera intestinal.
- Las alteraciones inducidas por la UPF pueden promover el crecimiento excesivo de bacterias patógenas (por ejemplo, Clostridium, Enterococcus).
Conclusiones:
- El consumo de UPF contribuye a la disbiosis intestinal, caracterizada por una diversidad microbiana reducida y una función de barrera deteriorada.
- Estos cambios microbianos y de barrera pueden promover enfermedades inmunomediadas como la EII.
- La disbiosis puede desencadenar respuestas inflamatorias, exacerbando la patogénesis de la EII.
Videos de Conceptos Relacionados
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
413
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
413
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
316
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
316
01:17Irritable Bowel Syndrome I: Introduction
369
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
369
01:17Chronic Bowel Disorders: Introduction
540
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
540
01:30Inflammatory Bowel Disease II: Crohn's Disease
375
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
375
01:29Inflammatory Bowel Disease IV: Pharmacological Management
185
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
185