Video Experimental Relacionado

Updated: Sep 9, 2025

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Published on: September 25, 2017

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Análisis de reutilización de la nitroxolina (8-hidroxi-5-nitroquinolina) como un compuesto anticaga

Carlos J Bethencourt-Estrella1,2,3, Atteneri López-Arencibia1,2,3, Isabel M Calero-Docina1

  • 1Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Spain.

Pharmaceuticals (Basel, Switzerland)
|August 28, 2025
PubMed
Resumen

La nitroxolina se muestra prometedora como un medicamento reutilizado para la enfermedad de Chagas, mostrando una mayor eficacia que el benznidazol contra el Trypanosoma cruzi. Induce la muerte celular programada, lo que sugiere un perfil terapéutico más seguro para esta enfermedad tropical descuidada.

Palabras clave:
La enfermedad de ChagasTripanosoma cruzi y sus derivadosla quimioterapianitroxolina y sus derivadosmuerte celular programada (DCP)Quínolina y sus derivados

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