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Manifestaciones clínicas, evasión inmune e implicaciones para la salud pública de la viruela del mono: desafíos y
Bhumika Parashar1, Rishabha Malviya1, Sathvik Belagodu Sridhar2
1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.
Infectious disorders drug targets
|August 28, 2025
Resumen
La viruela del mono (Mpox) presenta fiebre, erupción cutánea y linfadenopatía, con un aumento de la transmisión de persona a persona que plantea desafíos globales. Comprender sus variados efectos clínicos, especialmente en grupos vulnerables, es crucial para estrategias eficaces de prevención y tratamiento.
Área de la Ciencia:
- Enfermedades infecciosas
- Salud pública
- Virología
Sus antecedentes:
- Monkeypox (Mpox) es una enfermedad viral transmitida por contacto directo.
- La reciente expansión mundial de las regiones endémicas a las no endémicas plantea importantes preocupaciones de salud pública.
- Comprender las consecuencias clínicas y la dinámica de transmisión es fundamental.
Objetivo del estudio:
- Revisar y sintetizar los datos clínicos actuales sobre la viruela del mono (Mpox).
- Para analizar los mecanismos de evasión inmunológica empleados por el virus.
- Evaluar los desafíos de salud pública relacionados con los brotes de Mpox.
Principales métodos:
- Revisión completa de la literatura utilizando las bases de datos de PubMed, Scopus y Web of Science.
- Análisis centrado en las presentaciones clínicas, la evasión inmunológica y los informes de salud pública.
- Síntesis de los resultados para identificar las principales tendencias y desafíos.
Principales resultados:
- Mpox se presenta comúnmente con fiebre, sarpullido y linfadenopatía.
- Se observó la aparición de estrategias de evasión inmune viral y un aumento de la transmisión de persona a persona.
- Desafíos significativos identificados para la vigilancia mundial, la vacunación y la preparación para el brote.
Conclusiones:
- Mpox presenta diversas manifestaciones clínicas, con severos impactos en poblaciones vulnerables (por ejemplo, coinfección por VIH, afectación ocular).
- Las estrategias de evasión inmune presentan desafíos críticos para el desarrollo de tratamientos efectivos y medidas preventivas.
- Las intervenciones específicas, los diagnósticos mejorados y las estrategias de salud pública mejoradas son esenciales para la gestión de Mpox.
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