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IVCDB: una base de datos completa de iridovirus para la epidemiología, la evolución genética y el manejo de
Mincong Liang1, Weiqiang Pan1, Zhengqi Feng1
1State Key Laboratory for Biocontrol & Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Province Key Laboratory of Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Nucleic acids research
|August 28, 2025
Resumen
Una nueva base de datos, IVCDB, consolida los datos de iridovirus, abordando las limitaciones en la investigación. Este recurso ayuda a comprender la transmisión viral, el control de enfermedades y los esfuerzos de conservación del huésped.
Área de la Ciencia:
- Virología
- La bioinformática
- Ecología
Sus antecedentes:
- Los iridovirus infectan a más de 200 especies ectotérmicas, causando pérdidas económicas y disminuciones de la población.
- La investigación se ve obstaculizada por datos fragmentados, una taxonomía poco clara y herramientas de visualización deficientes.
Objetivo del estudio:
- Crear una base de datos completa (IVCDB) para la investigación sobre el iridovirus.
- Proporcionar herramientas para la integración de datos, el análisis taxonómico y la visualización espacio-temporal.
Principales métodos:
- Datos consolidados multidimensionales de iridovirus, incluidos 310 aislamientos de virus y 4378 proteínas virales.
- Desarrolló una tubería estandarizada de anotación del genoma y herramientas de análisis filogenético.
- Datos integrados sobre el rango de huéspedes, la vacuna y el método de detección en una base de conocimientos.
Principales resultados:
- IVCDB ofrece datos seleccionados sobre aislamientos de iridovirus geográficamente distintos.
- Incluye un sistema de visualización geoespacial interactivo y una base de datos de proteínas no redundantes.
- Proporciona herramientas de análisis filogenético y de colinealidad para la clasificación taxonómica.
Conclusiones:
- El IVCDB aborda los principales cuellos de botella de la investigación en los estudios de iridovirus.
- Apoya el control de enfermedades, la conservación del huésped y la comprensión de la transmisión viral entre especies.
- Facilita la identificación de nuevas especies y el análisis taxonómico.
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