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Declaración de consenso mundial sobre el manejo del embarazo en la enfermedad inflamatoria intestinal
Uma Mahadevan1, Cynthia H Seow2, Edward L Barnes3
1Division of Gastroenterology, Department of Medicine, University of California, San Francisco, California, USA.
Alimentary pharmacology & therapeutics
|August 28, 2025
Resumen
Este estudio proporciona un consenso global sobre el manejo de la enfermedad inflamatoria intestinal (EII) durante el embarazo, ofreciendo orientación basada en datos para mejorar los resultados de salud materna e infantil.
Área de la Ciencia:
- Gastroenterología
- Obstetricia y parto
- Salud pública
Sus antecedentes:
- El embarazo en mujeres con enfermedad inflamatoria intestinal (EII) presenta desafíos únicos debido a la escasez de datos de alta calidad sobre el tratamiento y el manejo.
- La falta de conocimiento entre pacientes y proveedores contribuye a prácticas variadas, impactando las tasas de embarazo, la adherencia a la medicación y los resultados de salud.
- Las directrices internacionales contradictorias ponen de relieve la necesidad de recomendaciones estandarizadas y basadas en la evidencia.
Objetivo del estudio:
- Establecer un consenso mundial sobre las mejores prácticas para el tratamiento de la enfermedad inflamatoria intestinal (EII) en mujeres embarazadas.
- Abordar las lagunas de conocimiento y estandarizar la atención de las pacientes con EII durante el embarazo.
- Desarrollar orientaciones basadas en datos para mejorar los resultados de la salud materna e infantil.
Principales métodos:
- Utilizó el proceso GRADE (Clasificación de Evaluación, Desarrollo y Evaluación de Recomendaciones) para recomendaciones basadas en datos.
- Utilizó el proceso RAND para áreas que requieren consenso de expertos donde los datos publicados eran insuficientes.
- Priorizar la salud materna como la piedra angular para apoyar la salud infantil en todas las recomendaciones.
Principales resultados:
- Desarrolló 34 recomendaciones GRADE y 35 declaraciones de consenso en diez categorías temáticas clave.
- Sintetizó los datos actuales y el dictamen de expertos para formular una guía integral.
- Se han identificado áreas que requieren una mayor investigación para fortalecer la práctica basada en la evidencia.
Conclusiones:
- El Consorcio Global de Consenso proporciona orientación práctica y basada en datos para el manejo global de la EII en el embarazo.
- Tiene como objetivo mejorar la consistencia de la atención y mejorar los resultados para las mujeres embarazadas con EII y sus bebés.
- Hace hincapié en la importancia de la colaboración internacional entre expertos y defensores de los pacientes para refinar la práctica clínica.
Palabras clave:
La enfermedad de CrohnInhibidores de la JAKProductos biológicosEnfermedad inflamatoria del intestinoembarazoColitis ulcerosa en el hígadoMás Videos Relacionados
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