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Declaración de consenso mundial sobre el manejo del embarazo en la enfermedad inflamatoria intestinal

Uma Mahadevan¹, Cynthia H Seow², Edward L Barnes³

¹Division of Gastroenterology, Department of Medicine, University of California, San Francisco, California.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

|August 28, 2025

Resumen

Este consenso global proporciona orientación basada en la evidencia para el manejo de la enfermedad inflamatoria intestinal (EII) en mujeres embarazadas, con el objetivo de mejorar los resultados de salud materna e infantil a través de prácticas de atención estandarizadas.

Área de la Ciencia:

Gastroenterología
Obstetricia y parto
Salud pública

Sus antecedentes:

El embarazo en mujeres con enfermedad inflamatoria intestinal (EII) presenta riesgos significativos.
Existen estudios y datos limitados de alta calidad sobre los medicamentos para EII durante el embarazo.
El conocimiento variado de los proveedores y las pautas globales crean confusión en la atención del embarazo con EII.

Objetivo del estudio:

Establecer una guía práctica basada en datos para el manejo de la EII en mujeres embarazadas a nivel mundial.
Abordar las lagunas de conocimiento y estandarizar la atención de las pacientes con EII durante el embarazo.
Para mejorar las tasas de embarazo, la adherencia a la medicación y los resultados para las mujeres con EII.

Principales métodos:

Utilizó el proceso GRADE (Clasificación de Evaluación, Desarrollo y Evaluación de Recomendaciones) para áreas ricas en datos.
Empleado el proceso RAND (Investigación y Desarrollo) para el consenso basado en opiniones de expertos.
La salud materna priorizada como fundamento para una salud infantil óptima.

Principales resultados:

Desarrolló 34 recomendaciones GRADE y 35 declaraciones de consenso en diez temas clave.
Sintetizó los datos actuales y las opiniones de los expertos para formar directrices integrales.
Se abordaron aspectos críticos del manejo de la EII durante el embarazo.

Conclusiones:

El objetivo del consorcio era ofrecer una guía práctica basada en la investigación para mejorar la atención global del embarazo con EII.
Su objetivo es reducir la confusión y promover una atención coherente y de alta calidad para las mujeres embarazadas con EII.
Hace hincapié en la importancia de la evidencia y el consenso de los expertos en el manejo de esta compleja población de pacientes.

Palabras clave:

Productos biológicos Enfermedad de Crohn Enfermedad inflamatoria intestinal Inhibidores de las JAK El embarazo La colitis ulcerosa

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