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Sistemas de administración de fármacos de nanopartículas para la aterosclerosis: orientación de precisión, modulación

Yunqi Zhang¹, Feifei Li², Libo Liu¹

¹Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|August 28, 2025

Resumen

Los sistemas de administración de fármacos de nanopartículas (NDDS) ofrecen un tratamiento avanzado de la aterosclerosis al dirigirse a las lesiones y responder a los microambientes de placa. Estos sistemas mejoran la eficacia y reducen los efectos secundarios en comparación con los métodos tradicionales.

Área de la Ciencia:

Medicina cardiovascular
Ingeniería biomédica
Nanotecnología

Sus antecedentes:

La aterosclerosis es una causa importante de enfermedades cardiovasculares con patogénesis compleja.
Los tratamientos actuales se enfrentan a limitaciones debido a la naturaleza multifacética de la enfermedad.

Objetivo del estudio:

Revisar los mecanismos fisiopatológicos de la aterosclerosis.
Examinar los avances en los sistemas de administración de fármacos de nanopartículas (NDDS) para el tratamiento de la aterosclerosis.

Principales métodos:

Revisión sistemática de los mecanismos fisiopatológicos.
Análisis de los desarrollos recientes en NDDS para la terapia dirigida de la aterosclerosis.

Principales resultados:

Los NDDS pueden modular las actividades celulares involucradas en la progresión aterosclerótica.
La administración dirigida y la liberación sensible al estímulo mejoran la eficacia terapéutica.
Los NDDS minimizan los efectos adversos sistémicos y fuera del objetivo.

Conclusiones:

Los NDDS superan las limitaciones de los tratamientos farmacológicos tradicionales para la aterosclerosis.
Las intervenciones personalizadas que utilizan NDDS pueden atenuar la progresión de la enfermedad, estabilizar las placas y promover la regresión.
Los NDDS tienen un potencial transformador para redefinir los paradigmas de tratamiento de la aterosclerosis y mejorar los resultados de los pacientes.

Palabras clave:

la aterosclerosis Entrega de drogas la nanomedicina las nanopartículas

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