Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview01:07

Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview

3.3K
In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
3.3K
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism01:26

Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism

3.6K
The Hofmann and Curtius rearrangement reactions can be applied to synthesize primary amines from carboxylic acid derivatives such as amides and acyl azides. In the Hofmann rearrangement, a primary amide undergoes deprotonation in the presence of a base, followed by halogenation to generate an N-haloamide. A second proton abstraction produces a stabilized anionic species, which rearranges to an isocyanate intermediate via an alkyl group migration from the carbonyl carbon to the neighboring...
3.6K
Preparation of 1° Amines: Azide Synthesis01:22

Preparation of 1° Amines: Azide Synthesis

4.1K
Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
4.1K
Preparation of Amides01:29

Preparation of Amides

3.2K
Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
3.2K
Amines to Amides: Acylation of Amines01:19

Amines to Amides: Acylation of Amines

2.7K
Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
2.7K
Acid Halides to Amides: Aminolysis01:07

Acid Halides to Amides: Aminolysis

3.1K
Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
3.1K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Effectiveness of Antenatal Craft Class on Management of Minor Ailments during Pregnancy among Primigravidae at a Tertiary Care Teaching Hospital.

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine·2026
Same author

Shedding light on the NN bond: unlocking rapid, catalyst-free direct hydroboration of azoarenes.

Chemical communications (Cambridge, England)·2026
Same author

Palladium-catalyzed synthesis of <i>S</i>-aryl thiocarbamates <i>via</i> desulfurative C-S cross-coupling reaction of dithiocarbamates.

Organic & biomolecular chemistry·2026
Same author

Manganese-Catalyzed Sulfonamidation of (Hetero)Aromatic C-H Bonds Using Direct Primary Sulfonamides: En Route to Late-Stage Diversified Sulfonamide Drugs.

Organic letters·2026
Same author

Ion-Gel-Driven Electroactive Phase Nucleation in PVDF-TrFE/MoS<sub>2</sub> Composites for High-Throughput Triboelectric Nanogenerators.

ACS applied materials & interfaces·2026
Same author

Copper-Catalyzed Selective Mononitration of Unbiased <i>ortho</i>-C-H Bonds in Arenes Using a Ball Mill in Air: Excellent Compatibility with Heterocycles.

Organic letters·2026

Video Experimental Relacionado

Updated: Sep 9, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

9.7K

Acoplamiento cruzado catalizado sostenido por Mn de amidas y sulfonamidas primarias con haluros de (hetero) arilo y

Sampa Mondal1, Keya Roy1, Parna Pramanik2

  • 1Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden, Howrah, West Bengal, 711103, India.

Chemistry, an Asian journal
|August 28, 2025
PubMed
Resumen

Este estudio introduce una eficiente reacción de acoplamiento catalizado por el cobre asistida por el manganeso para sintetizar N-arilo y N-estirilo amidas. El método rentable y libre de disolventes funciona en el aire y muestra un amplio alcance de sustrato y tolerancia de grupo funcional.

Palabras clave:
(Hetero) arilo y haluros de estiriloReacciones de acoplamiento cruzadoCondición de reacción limpiaAmidas primarias, sulfonamidas y cinamamidaCatalizador reutilizable de manganeso y cobre (MnCu)

Más Videos Relacionados

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
07:06

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis

Published on: February 16, 2020

8.3K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.6K

Videos de Experimentos Relacionados

Last Updated: Sep 9, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

9.7K
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
07:06

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis

Published on: February 16, 2020

8.3K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.6K

Área de la Ciencia:

  • Química orgánica
  • Catálisis
  • Química ecológica

Sus antecedentes:

  • Las reacciones de acoplamiento son vitales en la síntesis orgánica.
  • El desarrollo de sistemas catalíticos eficientes y sostenibles sigue siendo un desafío clave.

Objetivo del estudio:

  • Desarrollar una nueva reacción de acoplamiento cruzado catalizado por cobre asistido por manganeso, eficiente y sostenible.
  • Para sintetizar N-arilo y N-estilo amidas, sulfonamidas y cinamamidas.

Principales métodos:

  • Reacción de acoplamiento cruzado catalizada por cobre (Cu) asistida por manganeso (Mn).
  • La reacción se lleva a cabo en el aire, sin solventes ni ligandos añadidos.
  • Caracterización de las especies catalíticas mediante XPS, PXRD y SEM.

Principales resultados:

  • Se han obtenido rendimientos de buenos a excelentes para varias amidas de N-arilo y N-stirilo, sulfonamidas y cinamamidas.
  • Demostrado amplio alcance de sustrato (98 ejemplos) con tolerancia a diversos grupos funcionales.
  • Reutilización del catalizador (≥5 veces) y indicadores medioambientales favorables (factor E bajo y PMI).

Conclusiones:

  • El protocolo desarrollado ofrece un método rentable, ambientalmente benigno y escalable para la síntesis de amida.
  • Se propuso un nuevo ciclo catalítico basado en Mn-Cu basado en investigaciones mecanicistas.
  • Este trabajo promueve metodologías sostenibles de acoplamiento catalítico.