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Updated: Sep 9, 2025
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Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
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La sesamina mejora la colitis ulcerosa mediante la modulación del bucle de retroalimentación DUSP1/ERK y la
Shuxia Cao1, Xiangyu Guo1, Mengyuan Xin1
1Key Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji 133002, China.
Resumen
La sesamina (SSM) trata eficazmente la colitis ulcerosa (UC) reduciendo la inflamación y reparando la barrera intestinal. Este lignano vegetal modula la vía DUSP / ERK y mejora el equilibrio de la microbiota intestinal para un nuevo enfoque terapéutico.
Área de la Ciencia:
- Farmacología
- Gastroenterología
- Microbiología
Sus antecedentes:
- La sesamina (SSM), un lignano de las plantas, tiene propiedades antiinflamatorias e inmunomoduladoras conocidas.
- La colitis ulcerosa (UC) implica una patogénesis compleja que incluye daño intestinal, inflamación y disbiosis intestinal.
- Existen investigaciones limitadas sobre los efectos y mecanismos protectores del MUS en la UC.
Objetivo del estudio:
- Investigar los efectos protectores de la sesamina (SSM) en un modelo de ratón con colitis ulcerosa (UC).
- Para aclarar los mecanismos terapéuticos subyacentes a la acción de SSM en la UC, centrándose en la inflamación y la microbiota intestinal.
- Evaluar el impacto de la SSM en la barrera mucosa intestinal y la estructura microbiana intestinal.
Principales métodos:
- Se utilizó un modelo de UC inducido por dextrano sulfato de sodio (DSS) en ratones.
- Se utilizaron técnicas de biología molecular que incluyen tinción histológica, borrado occidental, proteómica y secuenciación de ARNr 16S.
- Se realizó un trasplante de microbiota fecal para evaluar el papel de la microbiota intestinal.
Principales resultados:
- SSM redujo significativamente la inflamación y reparó la barrera mucosa intestinal en ratones con UC (p < 0,05).
- SSM aumentó la regulación de la fosfatasa de doble especificidad 1 (DUSP1), suprimiendo la fosforilación de la proteína quinasa regulada por la señal extracelular (ERK), estableciendo un bucle de retroalimentación DUSP1/ERK.
- SSM mejoró la estructura de la microbiota intestinal aumentando las bacterias beneficiosas como Lactobacillus y disminuyendo los patógenos como Staphylococcus, restaurando la homeostasis (p < 0,05).
Conclusiones:
- Este estudio demuestra los efectos antiinflamatorios y de restauración de la barrera del SSM en la UC.
- El SSM modula el circuito de retroalimentación DUSP1/ERK y restaura la homeostasis de la microbiota intestinal.
- SSM presenta una nueva estrategia terapéutica para la colitis ulcerosa.
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