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Updated: Jun 2, 2026
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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
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Asociación de los parámetros de fibrinógeno y ROTEM con la edad y la raza en una población pediátrica diversa: un
Marium Malik1, Maha Al-Ghafry2, Maribel Lema3
1Department of Pediatric Hematology, Oncology and Blood & Marrow Transplant Program, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Journal of thrombosis and haemostasis : JTH
|August 28, 2025
Resumen
Este estudio revela el impacto de la edad y la raza en los resultados de las pruebas de coagulación en niños. Los intervalos de referencia pediátricos específicos de la raza para la tromboelastometría rotacional (ROTEM) son cruciales para el diagnóstico preciso.
Área de la Ciencia:
- Hematología
- Coagulación pediátrica
Sus antecedentes:
- La tromboelastometría rotacional (ROTEM) es un analizador viscoelástico para la evaluación de la coagulación global.
- Los intervalos de referencia pediátricos (IR) para ROTEM son escasos y a menudo no tienen en cuenta las variaciones raciales.
- Los IR discretos pueden conducir a una interpretación errónea del estado de coagulación.
Objetivo del estudio:
- Investigar la relación entre la edad y la raza con ROTEM y las pruebas convencionales de coagulación (CCT) en pacientes pediátricos.
- Establecer RI específicos para la edad y la raza para los parámetros ROTEM.
Principales métodos:
- Recopilación prospectiva de datos de 105 sujetos pediátricos de diferentes razas (entre 1 y 21 años).
- Se analizaron ROTEM y CCT (PT, aPTT, fibrinógeno).
- Cohorte analizado en su conjunto y estratificado por raza.
Principales resultados:
- La edad se correlacionó positivamente con el fibrinógeno, FIBTEM A10 y FIBTEM MCF en toda la cohorte.
- Los sujetos negros/afroamericanos (B/AA) mostraron diferencias relacionadas con la edad en los parámetros EXTEM y FIBTEM, lo que sugiere una tendencia protrombótica.
- Se observaron asociaciones significativas (p< 0,001) entre la edad y los parámetros específicos de ROTEM dentro del subgrupo B/ AA.
Conclusiones:
- Este estudio pone de relieve las variaciones en los parámetros de coagulación pediátrica relacionadas con la edad y específicas de cada raza.
- Los parámetros ROTEM pueden describirse como variables continuas influenciadas por la edad y la raza.
- La incorporación de poblaciones diversas para IR pediátricas específicas de la raza es esencial para mejorar la precisión del diagnóstico y el tratamiento personalizado.
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