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Expresión del ARN no codificante largo asociado al carcinoma de células escamosas cutáneas p38 inhibido circulante en

Vinit Sharma¹, Aditya Aggarwal², Justin Jacob¹

¹Department of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

The Indian journal of medical research

|August 29, 2025

Resumen

El PICSAR lncRNA sérico está significativamente regulado en pacientes con artritis reumatoide (AR). Este ARN largo no codificante muestra potencial como biomarcador no invasivo para el diagnóstico de AR.

Área de la Ciencia:

Biología molecular
Inmunología
Reumatología

Sus antecedentes:

La artritis reumatoide (AR) es una enfermedad articular inflamatoria crónica.
Los ARN largos no codificantes (ARNlnc) juegan un papel en la patogénesis de la AR.
La identificación de biomarcadores no invasivos para la AR es crucial.

Objetivo del estudio:

Investigar la expresión sérica del lncRNA cutáneo asociado al carcinoma de células escamosas inhibido por p38 (PICSAR lncRNA) en AR.
Evaluar el PICSAR lncRNA como un potencial biomarcador de diagnóstico no invasivo para la AR.

Principales métodos:

Se analizaron muestras de suero de 36 pacientes con AR y 20 controles sanos.
Se utilizó la PCR de transcripción inversa cuantitativa (qRT-PCR) para medir la expresión de PICSAR lncRNA durante 24 horas.
Se realizaron análisis de correlación y análisis de las características operativas del receptor (ROC).

Principales resultados:

PICSAR lncRNA fue significativamente regulado en pacientes con AR a las 0h y 6h en comparación con individuos sanos.
Se observaron niveles estables de PICSAR lncRNA hasta 24 horas en pacientes con AR.
El análisis de ROC indicó un potencial de diagnóstico sustancial con un área debajo de la curva (AUC) de 0,74.

Conclusiones:

PICSAR lncRNA está implicado en la patogénesis de la artritis reumatoide.
El PICSAR lncRNA sérico puede servir como un biomarcador no invasivo prometedor para el diagnóstico de AR.

Palabras clave:

El diagnóstico PICSAR ARN largo no codificante biomarcador no invasivo Artritis reumatoide en niños

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