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Enfermedad hepática estatótica asociada a la disfunción metabólica en el síndrome de Klinefelter: la alta prevalencia

Aldo Marrone¹, Francesca Allosso¹, Alfredo Caturano¹

¹Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

The Journal of clinical endocrinology and metabolism

|August 29, 2025

Resumen

Los pacientes con síndrome de Klinefelter (KS) tienen una alta prevalencia de enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD) en el 45, 1%. El síndrome metabólico es un predictor clave, destacando la necesidad de una detección temprana de MASLD en esta población.

Área de la Ciencia:

Endocrinología
Hepatología
Medicina cardiovascular

Sus antecedentes:

El síndrome de Klinefelter (KS) está asociado con un aumento de los riesgos metabólicos y cardiovasculares.
La prevalencia y las características de la enfermedad hepática esteatótica asociada a la disfunción metabólica (MASLD) siguen sin describirse en KS.

Objetivo del estudio:

Investigar la relación entre el hipogonadismo, la enfermedad hepática y el riesgo cardiovascular en pacientes con esclerosis quística.
Determinar la prevalencia y los predictores de MASLD en personas con síndrome de Klinefelter.

Principales métodos:

Estudio transversal de 82 pacientes con SK.
Los datos incluyeron antropometría, pruebas hormonales y de función hepática, y ultrasonido.
Esteatosis hepática evaluada por Fibroscan®/CAP; riesgo cardiovascular por Score2/Score2-Diabetes.

Principales resultados:

La prevalencia de MASLD fue del 45,1% en pacientes con SK.
Los pacientes con MASLD eran mayores, con un IMC más alto, una circunferencia de cintura y una prevalencia de diabetes.
El síndrome metabólico fue el único predictor independiente de MASLD; CAP se correlacionó negativamente con IGF-1 y positivamente con los triglicéridos, HOMA-IR, WC y IMC.

Conclusiones:

Este estudio revela una prevalencia sustancial de MASLD en el síndrome de Klinefelter.
El síndrome metabólico es un predictor significativo de MASLD en KS.
La identificación temprana de MASLD es crítica para el manejo de las complicaciones metabólicas en pacientes con SK.

Palabras clave:

Riesgo cardiometabólico FibroScan® es una herramienta El IGF-1 Síndrome de Klinefelter En el caso de los Las MetS

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