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Updated: Sep 9, 2025
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In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data
Published on: April 18, 2019
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[Encefalopatía traumática crónica]
R G Esin1,2, E A Gorobets1, O R Esin1,3
1Kazan (Volga region) Federal University, Kazan, Russia.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
|August 29, 2025
Resumen
La encefalopatía traumática crónica (CTE) es una enfermedad cerebral por impactos en la cabeza, que afecta a niños y adultos. El diagnóstico y el tratamiento tempranos, incluida la neuroprotección, son cruciales para controlar esta neurodegeneración progresiva.
Área de la Ciencia:
- Neurología
- La neurociencia
- Medicina del deporte
Sus antecedentes:
- La encefalopatía traumática crónica (ETC) es una enfermedad neurodegenerativa progresiva relacionada con impactos repetitivos en la cabeza.
- La condición afecta a los adultos y, preocupantemente, a la población pediátrica, lo que pone de relieve un problema urgente de salud pública.
Objetivo del estudio:
- Revisar y sintetizar la literatura actual sobre la ETC, centrándose en el diagnóstico y el tratamiento en niños y adolescentes.
- Analizar la patogénesis, la presentación clínica y las estrategias terapéuticas para la ETC.
Principales métodos:
- Revisión sistemática de la literatura a través de las bases de datos: eLibrary.ru, CyberLeninka, PubMed, Scopus y Google Scholar.
- Palabras clave utilizadas: "lesiones en la cabeza", "encefalopatía traumática", "diagnóstico", "tratamiento", "niños y adolescentes".
Principales resultados:
- La patogénesis de la ETC implica la formación de fosfato tau, el deterioro del aclaramiento de beta amiloide, la disfunción de la barrera hematoencefálica y la inflamación de bajo grado.
- Se describieron los criterios de diagnóstico del Instituto Nacional de Trastornos Neurológicos y Accidentes Cerebrovasculares (NINDS) para el síndrome de encefalopatía traumática en 2021.
- Las estrategias de tratamiento abarcan el manejo sintomático (ansiedad, depresión, problemas cognitivos / conductuales), la neuroprotección y las intervenciones no farmacológicas.
Conclusiones:
- El tratamiento eficaz de la ETC requiere comprender su compleja patogénesis y aplicar criterios de diagnóstico estandarizados.
- Los agentes neuroprotectores potenciales como la citicolina y el alfoscerato de colina merecen una mayor investigación para el tratamiento de la ETC.
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