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Señalización de la respuesta al daño por la vía de la adenosina extracelular: control del resultado de la infección

Manmeet Bhalla¹, Shaunna R Simmons¹, Alexsandra Lenhard¹

¹Department of Microbiology and Immunology, University at Buffalo School of Medicine, , Buffalo, New York, USA.

|August 29, 2025

Resumen

La adenosina extracelular, regulada por CD39 y CD73, modula la defensa del huésped contra las infecciones. Esta vía de señalización

Área de la Ciencia:

Inmunología
Señalización celular
Interacciones huésped-patógeno

Sus antecedentes:

El daño desencadena la liberación de adenosina, que señala a través de los receptores acoplados a la proteína G.
La adenosina extracelular es crucial para equilibrar el aclaramiento del patógeno y la inmunopatología.
El trabajo anterior se centró en el receptor A2B, lo que requirió una revisión más amplia.

Objetivo del estudio:

Para proporcionar una visión general de la señalización de la adenosina extracelular en la defensa del huésped.
Para discutir el papel de los receptores de adenosina en los resultados de la infección.
Explorar los cambios relacionados con la edad y el potencial terapéutico de esta vía.

Principales métodos:

Revisión de la literatura y síntesis de los estudios existentes.
Análisis de las funciones de los receptores de adenosina en modelos de infección.
Discusión de los hallazgos clínicos y traslacionales.

Principales resultados:

La adenosina extracelular juega un papel dependiente de la dosis y el tiempo en la infección.
Los receptores específicos de adenosina controlan diferencialmente las respuestas inmunes.
Las alteraciones relacionadas con la edad afectan a la susceptibilidad a las infecciones.

Conclusiones:

La vía de adenosina extracelular es un regulador crítico de la defensa del huésped.
Dirigirse a esta vía ofrece potencial terapéutico para las infecciones.
Se necesitan más investigaciones sobre la inmunosenescencia y las intervenciones farmacológicas.

Palabras clave:

El CD39 El CD73 La adenosina envejecimiento señalización de daños La inmunosenescencia Infecciones pulmonares Los neutrófilos Enfermedad pulmonar el tiempo

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