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Beneficios específicos de la edad de la vitamina D y su asociación con la mortalidad
Yan Wang1, Xueqin Zhang2, Xu Wang2
1Department of Rehabilitation, The affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
PloS one
|August 29, 2025
Resumen
Los niveles más altos de vitamina D están relacionados con un menor riesgo de mortalidad en todas las edades. Los adultos de 40 a 59 años pueden beneficiarse más del mantenimiento de un estado suficiente de vitamina D para reducir la mortalidad.
Área de la Ciencia:
- Endocrinología
- Salud pública
- Ciencias de la nutrición
Sus antecedentes:
- La vitamina D es crucial para la homeostasis del calcio, la salud ósea y otras funciones fisiológicas.
- La deficiencia de vitamina D está relacionada con un mayor riesgo de enfermedad y mortalidad.
- Estudios poblacionales limitados exploran el impacto de la vitamina D en la mortalidad en diversos grupos de edad.
Objetivo del estudio:
- Examinar la relación entre los niveles de 25-hidroxivitamina D y la mortalidad.
- Investigar el estado de la vitamina D y las correlaciones de mortalidad en una cohorte grande y diversa.
- Analizar las relaciones específicas de la edad entre la vitamina D y el riesgo de mortalidad.
Principales métodos:
- Análisis de una cohorte compuesta por 47.478 individuos de entre 18 y 85 años.
- Evaluación de la correlación entre los niveles de 25 ((OH) D y la mortalidad por cualquier causa.
- Análisis estratificado por edad y análisis de Cubic Spline Restricted (RCS) para determinar relaciones no lineales.
Principales resultados:
- Los niveles más altos de 25 ((OH) D se asociaron significativamente con una reducción de la mortalidad por cualquier causa.
- La reducción del riesgo de mortalidad fue más pronunciada en adultos de 40 a 59 años.
- Se observó una relación no lineal, con niveles óptimos de 25 ((OH) D que varían según la edad y el sexo.
Conclusiones:
- El estado de la vitamina D está significativamente asociado con la mortalidad general.
- El mantenimiento de niveles adecuados de vitamina D puede reducir el riesgo de mortalidad, especialmente en adultos de mediana edad.
- Se necesitan más investigaciones sobre las estrategias óptimas de suplementación de vitamina D.
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