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Patogénesis molecular impulsada por el virus de Epstein-Barr del carcinoma linfoepitelial pulmonar primario

Mingyuan Xie¹, Dong Yao¹, Liping Lei¹

¹Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.

Frontiers in oncology

|August 29, 2025

Resumen

El carcinoma linfoepitelial pulmonar primario (PLEC) es un cáncer de pulmón poco frecuente relacionado con el virus de Epstein-Barr (EBV). En esta revisión se detallan las

Área de la Ciencia:

En el campo de la oncología
Virología
Inmunología

Sus antecedentes:

El carcinoma linfoepitelial pulmonar primario (PLEC) es un cáncer de pulmón de células no pequeñas (CPNP) poco frecuente.
PLEC muestra una fuerte asociación con la infección por el virus de Epstein-Barr (EBV).
Se observan distintas predilecciones geográficas y étnicas en PLEC.

Objetivo del estudio:

Revisar los mecanismos oncogénicos impulsados por el EBV en el PLEC.
Para explorar la relación entre la infección por EBV, la progresión del tumor y el pronóstico clínico.
Para resumir la patología molecular, el microambiente inmune tumoral y las características clínico-patológicas de PLEC.

Principales métodos:

Revisión de la literatura sobre el PLEC y el EBV.
Análisis de datos de patología molecular.
Examen del microambiente inmune del tumor y de las características clínicas patológicas.

Principales resultados:

El EBV juega un papel importante en la patogénesis del PLEC.
Conocimiento del panorama molecular e inmunológico de PLEC.
Comprensión de las características clínicas y pronóstico de PLEC.

Conclusiones:

Los mecanismos impulsados por EBV son fundamentales para el desarrollo de PLEC.
Comprensión exhaustiva de la patología y los aspectos clínicos de PLEC.
Fundación para el desarrollo de estrategias dirigidas a EBV e inmunoterapéuticas para PLEC.

Palabras clave:

El virus de Epstein-Barr paisaje genómico inmunoterapia Carcinoma linfoepitelial del pulmón microambiente inmune al tumor

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