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Toxicidad ocular asociada a los inhibidores de MEK/BRAF: evaluación de la exactitud y exhaustividad de los grandes
Nila Kirupaharan1, Camellia Edalat1, Lauren A Dalvin2
1The Drexel University College of Medicine, Philadelphia, PA, USA.
Eye (London, England)
|August 29, 2025
Resumen
No abstract available in PubMed .
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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...