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Información sobre las medidas contra el sesgo en estudios de investigación no clínicos publicados: una comparación
Sara Steele1,2, Tom Lavrijssen3, Thomas Steckler3
1, Johnson & Johnson, Beerse, Belgium. SSteel10@its.jnj.com.
Research integrity and peer review
|August 29, 2025
Resumen
La información sobre las medidas de sesgo en la investigación en ciencias de la vida sigue siendo baja. Los informes de los experimentos in vivo son mejores que los in vitro, pero persisten diferencias significativas entre revistas.
Área de la Ciencia:
- Ciencias de la vida
- Investigación biomédica
Sus antecedentes:
- Las revisiones sistemáticas muestran una baja notificación de la mitigación del sesgo en la investigación no clínica de ciencias de la vida.
- Las medidas clave como la aleatorización, el cegamiento y la estimación del tamaño de la muestra son subreportadas.
Objetivo del estudio:
- Evaluar las normas de información recientes en artículos no clínicos, centrándose en la información estadística.
- Evaluar la prevalencia de informes de sesgo en una gran muestra de artículos de investigación biomédica.
Principales métodos:
- Selección aleatoria de 10 revistas de los Informes de Citación de Revistas (Clarivate).
- Análisis de 860 artículos de investigación biomédica publicados en 2020 utilizando una lista de verificación estandarizada.
- Categoría de los artículos en métodos in vivo, in vitro o combinados.
Principales resultados:
- Las tasas de notificación para la aleatorización variaron ampliamente (0% - 63% para in vivo, 0% - 4% para in vitro).
- Los informes de conducta ciega también mostraron variaciones significativas (11% - 71% para in vivo, 0% - 86% para in vitro).
- Los estudios in vivo generalmente tuvieron tasas de notificación más altas para estas medidas en comparación con los estudios in vitro.
Conclusiones:
- Los estándares de información para las medidas de sesgo y la información estadística siguen siendo subóptimos.
- Hay diferencias notables en la calidad de los informes entre los artículos experimentales in vivo e in vitro.
- Se observó una variabilidad significativa entre revistas en las normas de notificación.
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