Video Experimental Relacionado

Updated: Sep 9, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

Correlaciones inmunológicas y mecanismos de eficacia de la terapia TIL: conocimientos actuales y lagunas de

Blanca Navarro Rodrigo¹, Yaquelin Ortiz Miranda², Jesús Corria-Osorio²

¹Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Agora Cancer Research Center, Lausanne, Switzerland; Center for Cell Therapy, CHUV-Ludwig Institute, Lausanne, Switzerland; Immuno-oncology Service, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.

Trends in cancer

|August 30, 2025

Resumen

La terapia de linfocitos infiltrados en el tumor (TIL) es prometedora en el tratamiento del cáncer, especialmente después de la reciente aprobación de la FDA para el melanoma. Los avances en la comprensión de las TIL y el microambiente tumoral (TME) están allanando el camino para aplicaciones más amplias en tumores sólidos.

Área de la Ciencia:

Inmunología
En el campo de la oncología
Inmunoterapia contra el cáncer

Sus antecedentes:

La terapia de linfocitos infiltrados en el tumor (TIL, por sus siglas en inglés) es un campo que avanza rápidamente en el tratamiento del cáncer.
La reciente aprobación de la FDA de lifileucel para el melanoma avanzado marca un hito significativo.
La comprensión de los mecanismos inmunológicos de la terapia TIL es crucial para su optimización.

Objetivo del estudio:

Sintetizar los conocimientos actuales sobre correlatos inmunológicos y mecanismos de eficacia del tratamiento con TIL.
Para resaltar las funciones de la inmunogenicidad tumoral, los estados funcionales de la LTI y el microambiente tumoral (EMT).
Discutir los avances recientes y las direcciones futuras en el desarrollo de la terapia TIL.

Principales métodos:

Revisión de la literatura científica actual sobre el tratamiento con TIL.
Análisis de los datos de perfiles unicelulares y descubrimiento de biomarcadores en la terapia TIL.
Examen de nuevos protocolos de expansión de TIL y estrategias de ingeniería.

Principales resultados:

La eficacia del tratamiento con ILT está relacionada con la inmunogenicidad tumoral, los estados funcionales de ILT y la EMT.
Los perfiles unicelulares y los biomarcadores ayudan en la selección de pacientes y la optimización de la terapia.
Los nuevos enfoques están expandiendo la aplicabilidad de la terapia TIL a varios cánceres sólidos.

Conclusiones:

Las terapias TIL de próxima generación son muy prometedoras para revolucionar el tratamiento del cáncer.
Es esencial una mayor investigación sobre los mecanismos de TIL y las interacciones de TME.
La terapia TIL está a punto de convertirse en una modalidad clave en una gama más amplia de tumores sólidos.

Palabras clave:

Terapia con TIL transferencia de células adoptivas Los biomarcadores correlaciones de eficacia Los linfocitos que se infiltran en el tumor

Más Videos Relacionados

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Videos de Conceptos Relacionados

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...